C57BL/6NTac-Gck^em1(IMPC)H/H

Status	Available to order
EMMA ID	EM:11373
International strain name	C57BL/6NTac-Gck^em1(IMPC)H/H
Alternative name
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Gck^em1(IMPC)H
Gene/Transgene symbol	Gck

Information from provider

Provider	MRC, Medical Research Council
Provider affiliation	Mammalian Genetics Unit, Mary Lyon Centre at MRC Harwell
Genetic information	This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archiving	heterozygous C57BL/6NTacUSA, heterozygous C57BL/6NTacUSA

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Hyperinsulinism due to glucokinase deficiency / Orphanet_79299
MODY / Orphanet_552
Permanent neonatal diabetes mellitus / Orphanet_99885

IMPC phenotypes (allele matching)

increased circulating alkaline phosphatase level / IMPC
impaired glucose tolerance / IMPC
increased circulating glucose level / IMPC
increased circulating fructosamine level / IMPC
preweaning lethality, incomplete penetrance / IMPC
increased fasted circulating glucose level / IMPC

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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C57BL/6NTac-Gckem1(IMPC)H/H