AnxA1tg
| Status | Available to order |
| EMMA ID | EM:11385 |
| International strain name | AnxA1tg |
| Alternative name | AnxA1tg |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Unknown at present |
| Gene/Transgene symbol | Tg(CD2-Anxa1) |
Information from provider
| Provider | Fulvio D'Acquisto |
| Provider affiliation | Centre for Biochemical Pharmacology, William Harvey Research Institute, Queen Mary University of London |
| Genetic information | Annexin-a1 transgenic mice |
| Phenotypic information | Homozygous:Transgenic mice overexpressing Annexin-A1 in T cells. T cells from these mice show a lower threshold of TCR activation in vitro. They develop more severe signs of autoimmunity in the experimental autoimmune encephalomyelitis (EAE) and pristane-induced lupus. They also present a basal higher level of anxiety-like behavior.Heterozygous:Transgenic mice overexpressing Annexin-A1 in T cells. T cells from these mice show a lower threshold of TCR activation in vitro. They develop more severe signs of autoimmunity in the EAE and pristane-induced lupus. They also present a basal higher level of anxiety-like behavior. |
| Breeding history | Mice have been first backcrossed on C57BL/6 background and then intercrossed to generate AnxA1tg+/+ |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |