MGI phenotypes (allele matching)
- decreased rhombomere 3 size / MGI
STOCK Egr2tm3Pch Egr3tm1Jmi Tg(CD2-icre)4Kio/H
| Status | Available to order |
| EMMA ID | EM:11389 |
| International strain name | STOCK Egr2tm3Pch Egr3tm1Jmi Tg(CD2-icre)4Kio/H |
| Alternative name | CD2-Egr2/3 KO mouse |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Egr3tm1Jmi, |
| Gene/Transgene symbol | Egr3 |
Information from provider
| Provider | Suling Li |
| Provider affiliation | Life Science, Brunel University |
| Genetic information | Egr3-/- and CD2-specific Egr2-/- (CD2-Egr2-/- Egr3-/-) mice were generated by interbreeding Egr3-/- (Tourtellotte and Milbrandt, 1998) and CD2-specific Egr2 -/- mice (Zhu et al., 2008) on the C57BL/6 background. |
| Phenotypic information | Homozygous:The KO mice with deletion of both transcription factors Egr2 and Egr3 in lymphocytes resulted in a lethal autoimmune syndrome with excessive serum proinflammatory cytokines but also impaired antigen receptor-induced proliferation of B and T cells.Heterozygous:Inflammation similar as homozygous but less severe. |
| Breeding history | C57BL/6 with 129/SvJ |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Dejerine-Sottas syndrome / Orphanet_64748
- Charcot-Marie-Tooth disease type 1D / Orphanet_101084
- Charcot-Marie-Tooth disease type 4E / Orphanet_99951