B6.Cg-Tg(Mx1-cre)1Cgn/CgnCnrm
| Status | Available to order |
| EMMA ID | EM:01143 |
| International strain name | B6.Cg-Tg(Mx1-cre)1Cgn/CgnCnrm |
| Alternative name | B6-Mx1-Cre |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Mx1-cre)1Cgn, |
| Gene/Transgene symbol | Tg(Mx1-cre)1Cgn |
Information from provider
| Provider | Klaus Rajewsky |
| Provider affiliation | CBR Institute for Biomedical Research, Immune Disease Institute |
| Genetic information | Original transgene construct for expression of cre recombinase under the control of an inducible Mx1 (myxovirus resistance 1) promoter. The transgene expression is induced in vivo by administration of interferon alpha, interferon beta, or synthetic double-stranded RNA. The level of expression is maximal in the liver and in lymphocytes and lower in other tissues. |
| Phenotypic information | Original strain for the inducible in vivo expression of cre recombinase by administration of interferon alpha, interferon beta, or synthetic double-stranded RNA. Transgenic mice can be crossed to mice carrying floxed gene targets for their inducible deletion in vivo in the liver and in lymphocytes. |
| Breeding history | (C57BL/6 x CBA/2)F2 background; backcrossed to C57BL/6 (more than 10 generations) |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Inducible gene targeting in mice.;Kühn R, Schwenk F, Aguet M, Rajewsky K, ;1995;Science (New York, N.Y.);269;1427-9; 7660125