MGI phenotypes (allele matching)
- enlarged spleen / MGI
B6.129P2-Lyz2tm1(cre)Ifo/CgnCnrm
| Status | Available to order |
| EMMA ID | EM:01145 |
| International strain name | B6.129P2-Lyz2tm1(cre)Ifo/CgnCnrm |
| Alternative name | Lyzs-Cre |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Lyz2tm1(cre)Ifo, |
| Gene/Transgene symbol | Lyz2 |
Information from provider
| Provider | Klaus Rajewsky |
| Provider affiliation | CBR Institute for Biomedical Research, Immune Disease Institute |
| Genetic information | This strain expresses the cre recombinase protein in myeloid cells due to targeted insertion of the cre cDNA into their endogenous M lysozyme (Lyz2) locus. An NLS-cre gene was inserted into the endogenous ATG start site of the endogenous Lyz2 gene. An frt-flanked neomycin cassette was removed in ES cells via Flp-mediated recombination prior to production of chimeric mice. |
| Phenotypic information | This strain allows in vivo conditional gene targeting in macrophages and granulocytes. |
| Breeding history | Backcrossed to C57BL/6 (6-7 generations) |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Conditional gene targeting in macrophages and granulocytes using LysMcre mice.;Clausen B E, Burkhardt C, Reith W, Renkawitz R, Förster I, ;1999;Transgenic research;8;265-77; 10621974