MGI phenotypes (allele matching)
B6N.129(Cg)-Panx1tm1.1Fama/Cnrm
| Status | Available to order |
| EMMA ID | EM:11476 |
| International strain name | B6N.129(Cg)-Panx1tm1.1Fama/Cnrm |
| Alternative name | Panx1tm1Mony |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Panx1tm1.1Fama, |
| Gene/Transgene symbol | Panx1 |
Information from provider
| Provider | Fabio Mammano |
| Provider affiliation | IBCN, CNR |
| Additional owner | Prof. Hannah Monyer, Abt. Klinische Neurobiologie des Universitätsklinikums, DKFZ, Heidelberg, Germany |
| Genetic information | These mice were generated by introducing a lacZ and a neomycin cassette within exon 1 of Panx1. After removal of the neomycin cassette by breeding with cre recombinase–deleter, mice were backcrossed to C57BL/6. Breeding of heterozygous mice yielded Panx1-/- mice at a Mendelian ratio. |
| Phenotypic information | Homozygous:The mice are viable and show no obvious developmental or behavioral abnormality.Heterozygous:The mice are viable and show no obvious developmental or behavioral abnormality. |
| Breeding history | Homozygous Panx1-/- mice were outcrossed to C57BL/6N after arrival in Monterotondo. More than 5 backcrosses to C57BL/6N were performed. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Female infertility due to oocyte meiotic arrest / Orphanet_488191
Literature references
- ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear.;Anselmi Fabio, Hernandez Victor H, Crispino Giulia, Seydel Anke, Ortolano Saida, Roper Stephen D, Kessaris Nicoletta, Richardson William, Rickheit Gesa, Filippov Mikhail A, Monyer Hannah, Mammano Fabio, ;2008;Proceedings of the National Academy of Sciences of the United States of America;105;18770-5; 19047635
- Pannexins in ischemia-induced neurodegeneration.;Bargiotas Panagiotis, Krenz Antje, Hormuzdi Sheriar G, Ridder Dirk A, Herb Anne, Barakat Waleed, Penuela Silvia, von Engelhardt Jakob, Monyer Hannah, Schwaninger Markus, ;2011;Proceedings of the National Academy of Sciences of the United States of America;108;20772-7; 22147915
- Promises and pitfalls of a Pannexin1 transgenic mouse line.;Hanstein Regina, Negoro Hiromitsu, Patel Naman K, Charollais Anne, Meda Paolo, Spray David C, Suadicani Sylvia O, Scemes Eliana, ;2013;Frontiers in pharmacology;4;61; 23675350
- Mouse Panx1 Is Dispensable for Hearing Acquisition and Auditory Function.;Zorzi Veronica, Paciello Fabiola, Ziraldo Gaia, Peres Chiara, Mazzarda Flavia, Nardin Chiara, Pasquini Miriam, Chiani Francesco, Raspa Marcello, Scavizzi Ferdinando, Carrer Andrea, Crispino Giulia, Ciubotaru Catalin D, Monyer Hannah, Fetoni Anna R, M Salvatore Anna, Mammano Fabio, ;2017;Frontiers in molecular neuroscience;10;379; 29234270