STOCK Gt(ROSA)26Sortm1(cre/ERT)Brn Gjb2tm1Ugds/Cnrm
| Status | Available to order |
| EMMA ID | EM:11488 |
| International strain name | STOCK Gt(ROSA)26Sortm1(cre/ERT)Brn Gjb2tm1Ugds/Cnrm |
| Alternative name | Cx26-Rosa26-CreERT2 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gt(ROSA)26Sortm1(cre/ERT)Brn, |
| Gene/Transgene symbol | Gt(ROSA)26Sor |
Information from provider
| Provider | Fabio Mammano |
| Provider affiliation | IBCN, CNR |
| Genetic information | Tamoxifen inducible deletion of connexin 26. |
| Phenotypic information | Homozygous:ABRs measured at postnatal day 21 (P21) were significantly elevated across a frequency range of 4–32 kHz.Heterozygous:Not available |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Porokeratotic eccrine ostial and dermal duct nevus / Orphanet_166286
- Palmoplantar keratoderma-deafness syndrome / Orphanet_2202
- Knuckle pads-leukonychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome / Orphanet_2698
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
- Keratoderma hereditarium mutilans / Orphanet_494
- KID syndrome / Orphanet_477
- Autosomal dominant non-syndromic sensorineural deafness type DFNA / Orphanet_90635
Literature references
- Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea.;Sun Yu, Tang Wenxue, Chang Qing, Wang Yunfeng, Kong Weijia, Lin Xi, ;2009;The Journal of comparative neurology;516;569-79; 19673007