- increased granulocyte number / MGI
- abnormal spleen morphology / MGI
- spleen hypoplasia / MGI
- decreased body size / MGI
- arrested B cell differentiation / MGI
- decreased IgM level / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- increased susceptibility to infection / MGI
- abnormal effector T cell morphology / MGI
- increased natural killer cell mediated cytotoxicity / MGI
- decreased double-positive T cell number / MGI
- increased macrophage cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- lymph node hypoplasia / MGI
- absent mature B cells / MGI
- abnormal T cell receptor V(D)J recombination / MGI
- abnormal immunoglobulin V(D)J recombination / MGI
- decreased thymocyte number / MGI
- lung inflammation / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal macrophage physiology / MGI
- colitis / MGI
- abnormal T-helper 1 physiology / MGI
- abnormal response to transplant / MGI
- abnormal interferon secretion / MGI
- abnormal chemokine secretion / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal intestinal mucosa morphology / MGI
- abnormal B cell morphology / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased double-negative T cell number / MGI
- increased double-negative T cell number / MGI
- decreased susceptibility to type IV hypersensitivity reaction / MGI
- abnormal stomach mucosa morphology / MGI
- abnormal intestinal epithelium morphology / MGI
- abnormal B cell number / MGI
- decreased pre-B cell number / MGI
- decreased mature B cell number / MGI
- increased immature B cell number / MGI
- decreased immature B cell number / MGI
- abnormal gamma-delta T cell differentiation / MGI
- autoimmune response / MGI
STOCK Ptprca Rag2tm1Fwa Tg(TcrLCMV)327Sdz/Orl
Status | Available to order |
EMMA ID | EM:11491 |
International strain name | STOCK Ptprca Rag2tm1Fwa Tg(TcrLCMV)327Sdz/Orl |
Alternative name | P14 rag-/- Ly5.1 |
Strain type | Spontaneous |
Allele/Transgene symbol | Ptprca, |
Gene/Transgene symbol | Ptprc |
Information from provider
Provider | Benedita Rocha |
Provider affiliation | Lymphocyte Population Biology Unit, CNRS URA 196, Institut Pasteur |
Additional owner | The producer is Dr Benedita Rocha (Institut Pasteur) and the strain was given to us. |
Genetic information | P14 TCR transgenic mice expressing a TCR specific for lymphocytic choriomeningitis virus (LMCV) epitope GP33-41 and backcrossed to the C57BL/6 Rag2-/- Ly5.1 background. |
Phenotypic information | Homozygous:The mice result from the crossing of P14 (TCR-Tg-/-) mice to the Rag2-/- Ly5.1 background in order to abolish endogenous TCR rearrangements. Thereby, these mice are a source of naïve monoclonal T cell population, which bears a single and defined TCR.Heterozygous:Unknown |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | not known |
Immunocompromised | not known |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous C57BL/6J, homozygous C57BL/6J |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- T-B+ severe combined immunodeficiency due to CD45 deficiency / Orphanet_169157
- Severe combined immunodeficiency due to complete RAG1/2 deficiency / Orphanet_331206
- Omenn syndrome / Orphanet_39041
- Combined immunodeficiency with granulomatosis / Orphanet_157949
MGI phenotypes (allele matching)
Literature references
- Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection.;Munitic Ivana, Decaluwe Hélène, Evaristo César, Lemos Sara, Wlodarczyk Myriam, Worth Andrew, Le Bon Agnès, Selin Liisa K, Rivière Yves, Di Santo James P, Borrow Persephone, Rocha Benedita, ;2009;Journal of virology;83;11795-807; 19726518
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).