STOCK Ptprca Rag2tm1Fwa Tg(TcrLCMV)327Sdz/Orl

Status

Available to order

EMMA IDEM:11491
International strain nameSTOCK Ptprca Rag2tm1Fwa Tg(TcrLCMV)327Sdz/Orl
Alternative nameP14 rag-/- Ly5.1
Strain typeSpontaneous
Allele/Transgene symbolPtprca,
Gene/Transgene symbolPtprc

Information from provider

ProviderBenedita Rocha
Provider affiliationLymphocyte Population Biology Unit, CNRS URA 196, Institut Pasteur
Additional ownerThe producer is Dr Benedita Rocha (Institut Pasteur) and the strain was given to us.
Genetic informationP14 TCR transgenic mice expressing a TCR specific for lymphocytic choriomeningitis virus (LMCV) epitope GP33-41 and backcrossed to the C57BL/6 Rag2-/- Ly5.1 background.
Phenotypic informationHomozygous:
The mice result from the crossing of P14 (TCR-Tg-/-) mice to the Rag2-/- Ly5.1 background in order to abolish endogenous TCR rearrangements. Thereby, these mice are a source of naïve monoclonal T cell population, which bears a single and defined TCR.

Heterozygous:
Unknown
References
  • Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection.;Munitic Ivana, Decaluwe Hélène, Evaristo César, Lemos Sara, Wlodarczyk Myriam, Worth Andrew, Le Bon Agnès, Selin Liisa K, Rivière Yves, Di Santo James P, Borrow Persephone, Rocha Benedita, ;2009;Journal of virology;83;11795-807; 19726518
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivinghomozygous C57BL/6J, homozygous C57BL/6J
Stage of embryos2-cell

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • increased granulocyte number / MGI
  • abnormal spleen morphology / MGI
  • spleen hypoplasia / MGI
  • decreased body size / MGI
  • arrested B cell differentiation / MGI
  • decreased IgM level / MGI
  • thymus hypoplasia / MGI
  • arrested T cell differentiation / MGI
  • increased susceptibility to infection / MGI
  • abnormal effector T cell morphology / MGI
  • increased natural killer cell mediated cytotoxicity / MGI
  • decreased double-positive T cell number / MGI
  • increased macrophage cell number / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • lymph node hypoplasia / MGI
  • absent mature B cells / MGI
  • abnormal T cell receptor V(D)J recombination / MGI
  • abnormal immunoglobulin V(D)J recombination / MGI
  • decreased thymocyte number / MGI
  • lung inflammation / MGI
  • increased susceptibility to bacterial infection / MGI
  • abnormal macrophage physiology / MGI
  • colitis / MGI
  • abnormal T-helper 1 physiology / MGI
  • abnormal response to transplant / MGI
  • abnormal interferon secretion / MGI
  • abnormal chemokine secretion / MGI
  • decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
  • abnormal intestinal mucosa morphology / MGI
  • abnormal B cell morphology / MGI
  • decreased susceptibility to parasitic infection / MGI
  • decreased double-negative T cell number / MGI
  • increased double-negative T cell number / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • abnormal stomach mucosa morphology / MGI
  • abnormal intestinal epithelium morphology / MGI
  • abnormal B cell number / MGI
  • decreased pre-B cell number / MGI
  • decreased mature B cell number / MGI
  • increased immature B cell number / MGI
  • decreased immature B cell number / MGI
  • abnormal gamma-delta T cell differentiation / MGI
  • autoimmune response / MGI

Literature references

  • Epitope specificity and relative clonal abundance do not affect CD8 differentiation patterns during lymphocytic choriomeningitis virus infection.;Munitic Ivana, Decaluwe Hélène, Evaristo César, Lemos Sara, Wlodarczyk Myriam, Worth Andrew, Le Bon Agnès, Selin Liisa K, Rivière Yves, Di Santo James P, Borrow Persephone, Rocha Benedita, ;2009;Journal of virology;83;11795-807; 19726518

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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