B6N.Cg-Jak1tm1c(EUCOMM)Hmgu/Biat

Status

Available to order

EMMA IDEM:11548
International strain nameB6N.Cg-Jak1tm1c(EUCOMM)Hmgu/Biat
Alternative nameC57BL/6N-A Jak1/Biat
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolJak1tm1c(EUCOMM)Hmgu,
Gene/Transgene symbolJak1

Information from provider

ProviderAlexander Dohnal
Provider affiliationTumor Immunology, St. Anna Kinderkrebsforschung
Genetic informationThis line originates from EUCOMM ES clone HEPD0646_3_H04, after breeding the resulting tm1a strain (EM:06879, C57BL/6N-Atm1Brd Jak1tm1a(EUCOMM)Hmgu/Biat) with a flp recombinase deleter line to convert the original targeted tm1a (knock-out first) allele into a conditional tm1c allele.
Phenotypic informationHomozygous:
none

Heterozygous:
none
References
  • Loss of JAK1 Drives Innate Immune Deficiency.;Witalisz-Siepracka Agnieszka, Klein Klara, Prinz Daniela, Leidenfrost Nicoletta, Schabbauer Gernot, Dohnal Alexander, Sexl Veronika, ;2018;Frontiers in immunology;9;3108; 30671064
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Autosomal recessive mendelian susceptibility to mycobacterial diseases due to partial JAK1 deficiency / Orphanet_574957

Literature references

  • Loss of JAK1 Drives Innate Immune Deficiency.;Witalisz-Siepracka Agnieszka, Klein Klara, Prinz Daniela, Leidenfrost Nicoletta, Schabbauer Gernot, Dohnal Alexander, Sexl Veronika, ;2018;Frontiers in immunology;9;3108; 30671064

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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