B6N.Cg-Mapkapk2^{tm1c(EUCOMM)Hmgu}/Biat

Status	Available to order
EMMA ID	EM:11549
International strain name	B6N.Cg-Mapkapk2^{tm1c(EUCOMM)Hmgu}/Biat
Alternative name	C57BL/6N-Mapkapk2/Biat
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Mapkapk2^{tm1c(EUCOMM)Hmgu},
Gene/Transgene symbol	Mapkapk2

Information from provider

Provider	Alexander Dohnal
Provider affiliation	Tumor Immunology, St. Anna Kinderkrebsforschung
Genetic information	Mapkapk2^{tm1a(EUCOMM)Hmgu}/H mice (EMMA strain EM:05658; EUCOMM clone HEPD0672_2_A02) were crossed with B6.129S4-Gt(ROSA)26Sor^tm1(FLP1)Dym/RainJ for flp recombinase-mediated deletion and production of conditional MK2 (or Mapkapk2) knock-out mice.
Phenotypic information	Homozygous: none Heterozygous: none
References	The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.;Soukup Klara, Halfmann Angela, Le Bras Marie, Sahin Emine, Vittori Sarah, Poyer Fiona, Schuh Cornelia, Luger Romana, Niederreiter Birgit, Haider Thomas, Stoiber Dagmar, Blüml Stephan, Schabbauer Gernot, Kotlyarov Alexey, Gaestel Matthias, Felzmann Thomas, Dohnal Alexander M, ;2015;Journal of immunology (Baltimore, Md. : 1950);195;541-52; 26078274
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	University of Veterinary Medicine, Vienna, Austria

Literature references

The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.;Soukup Klara, Halfmann Angela, Le Bras Marie, Sahin Emine, Vittori Sarah, Poyer Fiona, Schuh Cornelia, Luger Romana, Niederreiter Birgit, Haider Thomas, Stoiber Dagmar, Blüml Stephan, Schabbauer Gernot, Kotlyarov Alexey, Gaestel Matthias, Felzmann Thomas, Dohnal Alexander M, ;2015;Journal of immunology (Baltimore, Md. : 1950);195;541-52; 26078274

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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B6N.Cg-Mapkapk2tm1c(EUCOMM)Hmgu/Biat