C57BL/6J-Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Orl
| Status | Available to order |
| EMMA ID | EM:11621 |
| International strain name | C57BL/6J-Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Orl |
| Alternative name | JAS3-Rosa26-Zip14(L438R) |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh, |
| Gene/Transgene symbol | Gt(ROSA)26Sor |
Information from provider
| Provider | Wim Van Hul |
| Provider affiliation | University of Antwerp |
| Genetic information | This is a mutant mouse model with Zip14 (Slc39a14) L438R inserted in the Gt(ROSA)26Sor locus. A loxP-flanked transcriptional STOP cassette is incorporated between Zip14-L438R and a CAG promoter to allow the conditional overexpression of Zip14-L438R to be dependent upon the cre recombinase. |
| Phenotypic information | Homozygous:Homozygous Zip14 (flox) mice, with a loxP-flanked transcriptional STOP cassette still incorporated between Zip14-L438R and a CAG promoter, do not have a phenotype. Only crossing Zip14 (flox) mice with cre recombinase-expressing mice will result in active expression of Zip14-L438R and, possibly, a phenotype.Heterozygous:Heterozygous Zip14 (flox) mice, with a loxP-flanked transcriptional STOP cassette still incorporated between Zip14-L438R and a CAG promoter, do not have a phenotype. Only crossing Zip14 (flox) mice with cre recombinase-expressing mice will result in active expression of Zip14-L438R and, possibly, a phenotype. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J |