- abnormal coat/ hair morphology / MGI
- alopecia / MGI
- sparse hair / MGI
- delayed hair appearance / MGI
- enlarged sebaceous gland / MGI
- enlarged lymph nodes / MGI
- dermatitis / MGI
- skin lesions / MGI
- epidermal hyperplasia / MGI
- thick dermal layer / MGI
- decreased body size / MGI
- corneal opacity / MGI
- excessive scratching / MGI
- acanthosis / MGI
- abnormal hair growth / MGI
- abnormal hair follicle development / MGI
- abnormal hair shaft morphology / MGI
- abnormal external auditory canal morphology / MGI
- abnormal hair cycle catagen phase / MGI
- orthokeratosis / MGI
- integument phenotype / MGI
- dental pulp necrosis / MGI
- periodontal ligament necrosis / MGI
- abnormal leukocyte cell number / MGI
- abnormal thymus morphology / MGI
- thick epidermis / MGI
- abnormal lymph node morphology / MGI
- abnormal lymph node cortex morphology / MGI
- abnormal thymus lobule morphology / MGI
- abnormal immune system organ morphology / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- abnormal thymus corticomedullary boundary morphology / MGI
- dilated lymph node medullary sinus / MGI
- enlarged thymus cortex / MGI
- abnormal hair follicle morphology / MGI
- postnatal growth retardation / MGI
- increased inflammatory response / MGI
- liver inflammation / MGI
- thymus atrophy / MGI
- lymph node inflammation / MGI
- cachexia / MGI
- lymph node hyperplasia / MGI
- hypergranulosis / MGI
- rough coat / MGI
- postnatal lethality, incomplete penetrance / MGI
129S2.Cg-Ctslnkt/Orl
Status | Available to order |
EMMA ID | EM:01163 |
International strain name | 129S2.Cg-Ctslnkt/Orl |
Alternative name | nackt |
Strain type | Induced Mutant Strains : Radiation-induced |
Allele/Transgene symbol | Ctslnkt, |
Gene/Transgene symbol | Ctsl |
Information from provider
Provider | Jean-Louis Guénet |
Provider affiliation | Institut Pasteur |
Genetic information | Molecular analysis of the coding region in Ctsl-nackt mice revealed a 118 bp deletion involving the end of exon 6 and almost all of exon 7. Western blot analysis of skin from homozygous mutant mice indicated that no stable protein is produced. |
Phenotypic information | Hair and immunological defects. Homozygotes for the mutant allele exhibit partial hair-loss, skin defects, impaired T-cell maturation, dilated cardiomyopathy, and high postnatal mortality. Mutant males show both normal and atrophic seminiferous tubules and reduced sperm production. Alopecia by day 12 around neck and eyes, skin lesions in adult mice |
Breeding history | Homozygous x heterozygous. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency.;Benavides F, Giordano M, Fiette L, Bueno Brunialti A L, Martin Palenzuela N, Vanzulli S, Baldi P, Schmidt R, Dosne Pasqualini C, Guénet J, ;1999;Immunogenetics;49;413-9; 10199917
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