129S2.Cg-Ctslnkt/Orl

Status

Available to order

EMMA IDEM:01163
International strain name129S2.Cg-Ctslnkt/Orl
Alternative namenackt
Strain typeInduced Mutant Strains : Radiation-induced
Allele/Transgene symbolCtslnkt,
Gene/Transgene symbolCtsl

Information from provider

ProviderJean-Louis Guénet
Provider affiliationInstitut Pasteur
Genetic informationMolecular analysis of the coding region in Ctsl-nackt mice revealed a 118 bp deletion involving the end of exon 6 and almost all of exon 7. Western blot analysis of skin from homozygous mutant mice indicated that no stable protein is produced.
Phenotypic informationHair and immunological defects. Homozygotes for the mutant allele exhibit partial hair-loss, skin defects, impaired T-cell maturation, dilated cardiomyopathy, and high postnatal mortality. Mutant males show both normal and atrophic seminiferous tubules and reduced sperm production. Alopecia by day 12 around neck and eyes, skin lesions in adult mice
Breeding historyHomozygous x heterozygous.
References
  • Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency.;Benavides F, Giordano M, Fiette L, Bueno Brunialti A L, Martin Palenzuela N, Vanzulli S, Baldi P, Schmidt R, Dosne Pasqualini C, Guénet J, ;1999;Immunogenetics;49;413-9; 10199917

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal coat/ hair morphology / MGI
  • alopecia / MGI
  • sparse hair / MGI
  • delayed hair appearance / MGI
  • enlarged sebaceous gland / MGI
  • enlarged lymph nodes / MGI
  • dermatitis / MGI
  • skin lesions / MGI
  • epidermal hyperplasia / MGI
  • thick dermal layer / MGI
  • decreased body size / MGI
  • corneal opacity / MGI
  • excessive scratching / MGI
  • acanthosis / MGI
  • abnormal hair growth / MGI
  • abnormal hair follicle development / MGI
  • abnormal hair shaft morphology / MGI
  • abnormal external auditory canal morphology / MGI
  • abnormal hair cycle catagen phase / MGI
  • orthokeratosis / MGI
  • integument phenotype / MGI
  • dental pulp necrosis / MGI
  • periodontal ligament necrosis / MGI
  • abnormal leukocyte cell number / MGI
  • abnormal thymus morphology / MGI
  • thick epidermis / MGI
  • abnormal lymph node morphology / MGI
  • abnormal lymph node cortex morphology / MGI
  • abnormal thymus lobule morphology / MGI
  • abnormal immune system organ morphology / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • increased CD8-positive, alpha-beta T cell number / MGI
  • abnormal thymus corticomedullary boundary morphology / MGI
  • dilated lymph node medullary sinus / MGI
  • enlarged thymus cortex / MGI
  • abnormal hair follicle morphology / MGI
  • postnatal growth retardation / MGI
  • increased inflammatory response / MGI
  • liver inflammation / MGI
  • thymus atrophy / MGI
  • lymph node inflammation / MGI
  • cachexia / MGI
  • lymph node hyperplasia / MGI
  • hypergranulosis / MGI
  • rough coat / MGI
  • postnatal lethality, incomplete penetrance / MGI

Literature references

  • Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency.;Benavides F, Giordano M, Fiette L, Bueno Brunialti A L, Martin Palenzuela N, Vanzulli S, Baldi P, Schmidt R, Dosne Pasqualini C, Guénet J, ;1999;Immunogenetics;49;413-9; 10199917

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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