STOCK Dsg4lah/Orl

Status

Available to order

EMMA IDEM:01169
International strain nameSTOCK Dsg4lah/Orl
Alternative namelanceolate hair
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolDsg4lah,
Gene/Transgene symbolDsg4

Information from provider

ProviderXavier Montagutelli
Provider affiliationInstitut Pasteur
Genetic informationAn A to C transversion at nucleotide 587 within exon 6. The mutation causes a tyrosine to serine change at amino acid position 196 affecting a potential phosphorylation site.
Phenotypic informationMice carrying mutations at this locus exhibit abnormalities in hair growth, vibrissae growth, and a thickened epidermis.
Breeding historyBred by crossing heterozygous mice together or heterozygous by homozygous mutant mice.
References
  • Lanceolate hair (lah): a recessive mouse mutation with alopecia and abnormal hair.;Montagutelli X, Hogan M E, Aubin G, Lalouette A, Guénet J L, King L E, Sundberg J P, ;1996;The Journal of investigative dermatology;107;20-5; 8752833
  • Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris.;Kljuic Ana, Bazzi Hisham, Sundberg John P, Martinez-Mir Amalia, O'Shaughnessy Ryan, Mahoney My G, Levy Moise, Montagutelli Xavier, Ahmad Wasim, Aita Vincent M, Gordon Derek, Uitto Jouni, Whiting David, Ott Jurg, Fischer Stuart, Gilliam T Conrad, Jahoda Colin A B, Morris Rebecca J, Panteleyev Andrei A, Nguyen Vu Thuong, Christiano Angela M, ;2003;Cell;113;249-60; 12705872

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • distorted hair follicle pattern / MGI
  • alopecia / MGI
  • sparse hair / MGI
  • short hair / MGI
  • scaly skin / MGI
  • dermatitis / MGI
  • thick skin / MGI
  • thick epidermis / MGI
  • epidermal hyperplasia / MGI
  • hyperkeratosis / MGI
  • wavy vibrissae / MGI
  • short vibrissae / MGI
  • abnormal coat appearance / MGI
  • acanthosis / MGI
  • abnormal hair growth / MGI
  • abnormal hair texture / MGI
  • hair follicle degeneration / MGI
  • abnormal hair shaft morphology / MGI
  • abnormal hair cortex morphology / MGI
  • abnormal hair cycle anagen phase / MGI
  • abnormal hair cycle catagen phase / MGI
  • rough coat / MGI
  • hair follicle outer rooth sheath hyperplasia / MGI

Literature references

  • Lanceolate hair (lah): a recessive mouse mutation with alopecia and abnormal hair.;Montagutelli X, Hogan M E, Aubin G, Lalouette A, Guénet J L, King L E, Sundberg J P, ;1996;The Journal of investigative dermatology;107;20-5; 8752833
  • Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris.;Kljuic Ana, Bazzi Hisham, Sundberg John P, Martinez-Mir Amalia, O'Shaughnessy Ryan, Mahoney My G, Levy Moise, Montagutelli Xavier, Ahmad Wasim, Aita Vincent M, Gordon Derek, Uitto Jouni, Whiting David, Ott Jurg, Fischer Stuart, Gilliam T Conrad, Jahoda Colin A B, Morris Rebecca J, Panteleyev Andrei A, Nguyen Vu Thuong, Christiano Angela M, ;2003;Cell;113;249-60; 12705872

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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