B6.Cg-Mtortm1.1Gcon Eif4ebp1tm1Nso Eif4ebp2tm1Klan A1cfTg(Myh6-cre/Esr1*)1Jmk/Cnrm
| Status | Available to order |
| EMMA ID | EM:11705 |
| International strain name | B6.Cg-Mtortm1.1Gcon Eif4ebp1tm1Nso Eif4ebp2tm1Klan A1cfTg(Myh6-cre/Esr1*)1Jmk/Cnrm |
| Alternative name | ME |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Eif4ebp2tm1Klan, |
| Gene/Transgene symbol | Eif4ebp2 |
Information from provider
| Provider | Gianluigi Condorelli |
| Provider affiliation | Laboratory of Inflammation and Immunology in Cardiovascular Pathologies, Istituto Clinico Humanitas |
| Genetic information | B6/129 mTOR fl; 4EBP1-4EBP2 KO; MHC-MerCreMer Tg. These mTOR floxed mutant mice harbor loxP sites flanking exons 1-5 and the Cre recombinase is activated after Tamoxifen injection. Furthermore these mice are global KO for the eukaryotic translation initiation factor 4E binding protein 1 (4EBP1 Chr8) and 2 (4EBP2, Chr10). |
| Phenotypic information | Homozygous:No harmful phenotype.Heterozygous:No harmful phenotype. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Isolated focal cortical dysplasia type IIa / Orphanet_269001
- Isolated focal cortical dysplasia type IIb / Orphanet_269008
- Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome / Orphanet_457485
Literature references
- The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus.;Banko Jessica L, Poulin Francis, Hou Lingfei, DeMaria Christine T, Sonenberg Nahum, Klann Eric, ;2005;The Journal of neuroscience : the official journal of the Society for Neuroscience;25;9581-90; 16237163
- MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice.;Zhang Denghong, Contu Riccardo, Latronico Michael V G, Zhang Jianlin, Rizzi Roberto, Catalucci Daniele, Miyamoto Shigeki, Huang Katherine, Ceci Marcello, Gu Yusu, Dalton Nancy D, Peterson Kirk L, Guan Kun-Liang, Brown Joan Heller, Chen Ju, Sonenberg Nahum, Condorelli Gianluigi, ;2010;The Journal of clinical investigation;120;2805-16; 20644257