B6;129S5-Mdc1Gt(OST441263)Lex/Cnrm
| Status | Available to order |
| EMMA ID | EM:11817 |
| International strain name | B6;129S5-Mdc1Gt(OST441263)Lex/Cnrm |
| Alternative name | Mdc1+/- |
| Strain type | Gene-trap |
| Allele/Transgene symbol | Mdc1Gt(OST441263)Lex, |
| Gene/Transgene symbol | Mdc1 |
Information from provider
| Provider | Zhenkun Lou |
| Provider affiliation | Oncology, Mayo Clinic |
| Genetic information | Mdc1+/- mice were originally obtained injecting the ES clone (OST441263) from Lexicon Genetics into C57BL/6 blastocysts to generate chimeric mice. Splicing of the neomycin gene and flanking DNA produces a transcript that potentially disrupts the proper splicing of exons 1 and 2 of the Mdc1 gene |
| Phenotypic information | Homozygous:MDC1 knockout mice recapitulated many phenotypes of H2AX knockout mice, including growth retardation, male infertility, immune defects, chromosome instability, DNA repair defects, and radiation sensitivityHeterozygous:no described phenotype |
| References |
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| Homozygous fertile | no |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals.;Lou Zhenkun, Minter-Dykhouse Katherine, Franco Sonia, Gostissa Monica, Rivera Melissa A, Celeste Arkady, Manis John P, van Deursen Jan, Nussenzweig André, Paull Tanya T, Alt Frederick W, Chen Junjie, ;2006;Molecular cell;21;187-200; 16427009