- abnormal rib morphology / IMPC
- increased monocyte cell number / IMPC
- decreased leukocyte cell number / IMPC
- increased granulocyte number / IMPC
- abnormal cornea morphology / IMPC
- corneal opacity / IMPC
- abnormal iris morphology / IMPC
- abnormal eye pigmentation / IMPC
- abnormal eye morphology / IMPC
- abnormal eye size / IMPC
- abnormal eyelid aperture / IMPC
- decreased B cell number / IMPC
- decreased T cell number / IMPC
- corneal vascularization / IMPC
- increased hemoglobin content / IMPC
- absent pinna reflex / IMPC
- increased NK cell number / IMPC
- decreased CD4-positive, alpha beta T cell number / IMPC
- decreased CD8-positive, alpha-beta T cell number / IMPC
- decreased mature B cell number / IMPC
- increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
- increased effector memory CD4-positive, alpha-beta T cell number / IMPC
B6Brd;B6N-Tyrc-Brd Spns2tm1a(KOMP)Wtsi/Wtsi
Status | Available to order |
EMMA ID | EM:12059 |
International strain name | B6Brd;B6N-Tyrc-Brd Spns2tm1a(KOMP)Wtsi/Wtsi |
Alternative name | EPD0090_5_B04 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Spns2tm1a(KOMP)Wtsi, |
Gene/Transgene symbol | Spns2 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from KOMP ES clone EPD0090_5_B04. For further details on the construction of this clone see the page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Wellcome Trust Sanger Institute, Hinxton, United Kingdom |
Animals used for archiving | homozygous 0 |
Disease and phenotype information
IMPC phenotypes (allele matching)
MGI phenotypes (allele matching)
- increased monocyte cell number / MGI
- decreased leukocyte cell number / MGI
- increased granulocyte number / MGI
- microphthalmia / MGI
- cataract / MGI
- small lens / MGI
- abnormal cornea morphology / MGI
- increased incidence of corneal inflammation / MGI
- corneal opacity / MGI
- abnormal pupil morphology / MGI
- abnormal iris morphology / MGI
- abnormal eye pigmentation / MGI
- abnormal retina morphology / MGI
- abnormal humoral immune response / MGI
- decreased IgG level / MGI
- increased susceptibility to bacterial infection / MGI
- increased bone strength / MGI
- abnormal iridocorneal angle / MGI
- abnormal auditory brainstem response / MGI
- decreased B-1 B cell number / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- abnormal ciliary body morphology / MGI
- eyelids fail to open / MGI
- narrow eye opening / MGI
- abnormal corneal stroma morphology / MGI
- increased circulating bilirubin level / MGI
- immune system phenotype / MGI
- corneal vascularization / MGI
- decreased circulating glucose level / MGI
- absent pinna reflex / MGI
- increased NK T cell number / MGI
- increased NK cell number / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased follicular B cell number / MGI
- decreased mature B cell number / MGI
- decreased IgG1 level / MGI
- eye opacity / MGI
- increased bone mineral content / MGI
- abnormal behavior / MGI
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