MGI phenotypes (allele matching)
129S2/SvPas-Ins2tm1Jja/Orl
| Status | Available to order |
| EMMA ID | EM:01218 |
| International strain name | 129S2/SvPas-Ins2tm1Jja/Orl |
| Alternative name | Ins/2_LacZ_129 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ins2tm1Jja, |
| Gene/Transgene symbol | Ins2 |
Information from provider
| Provider | Jacques Jami |
| Provider affiliation | Endocrinologie pédiatrique, INSERM U561, Groupe Hospitalier Cochin - Saint Vincent de Paul, Institut Cochin |
| Genetic information | These mice carry a knock-out mutation of the gene coding for mouse proinsulin-2 (Ins2, or insulin II) and express LacZ in their islets. This property can be used for tracking proinsulin-2 expressing cells in the islets or thymus (see Chentoufi et al Diabetes 2004). |
| Phenotypic information | Deficiency of proinsulin expression by thymic epithelial cells |
| References |
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Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Literature references
- Phenotypic alterations in insulin-deficient mutant mice.;Duvillié B, Cordonnier N, Deltour L, Dandoy-Dron F, Itier J M, Monthioux E, Jami J, Joshi R L, Bucchini D, ;1997;Proceedings of the National Academy of Sciences of the United States of America;94;5137-40; 9144203