C3HeB/FeJ-Crybb2Aey2/Ieg

Status

Available to order

EMMA IDEM:12554
International strain nameC3HeB/FeJ-Crybb2Aey2/Ieg
Alternative nameAey2
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolCrybb2Aey2,
Gene/Transgene symbolCrybb2

Information from provider

ProviderJana Löster (formerly Kratochvilova)
Provider affiliationInstitut of Mammalian Genetics, Helmholtz Zentrum München
Additional ownerProf. Dr. Jochen Graw, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Developmental Genetics, Neuherberg/Germany
Genetic informationDominant mutation in chromosome 5, gene Crybb2 (T553A ; Val187Glu). Mutation generated by N-ethyl-N-nitrosourea (ENU)

Disclaimer - Special restrictions:

1) Mutant development was phenotype driven. Although for some mutant lines, linkage data and the molecular characterization of the causative mutation has been published, EMMA has not genotyped the strains and can not provide genotyping protocols.
2) Some lines showed low penetrance of the phenotype.
3) Only sperm available. Rederivation service can not be offered.
4) EMMA quality control standards may not apply for these strains.
5) EMMA has not verified the breeding performance and the genetic background of the strains.

The genotype/phenotype of the mice is not confirmed by INFRAFRONTIER/EMMA. We strongly recommend that the recipient confirms genotype/phenotype upon receipt.
Phenotypic informationHomozygous:
Progressive childhood cataract

Heterozygous:
Progressive childhood cataract
Breeding historyKept as homozygous line
References
  • Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse.;Graw J, Löster J, Soewarto D, Fuchs H, Reis A, Wolf E, Balling R, Hrabé de Angelis M, ;2001;Investigative ophthalmology & visual science;42;1574-80; 11381063
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

Literature references

  • Aey2, a new mutation in the betaB2-crystallin-encoding gene of the mouse.;Graw J, Löster J, Soewarto D, Fuchs H, Reis A, Wolf E, Balling R, Hrabé de Angelis M, ;2001;Investigative ophthalmology & visual science;42;1574-80; 11381063

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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