C57BL/6-Ccr2tm1(cre/ERT2,mKate2)Arte/Orl
| Status | Available to order |
| EMMA ID | EM:12698 |
| International strain name | C57BL/6-Ccr2tm1(cre/ERT2,mKate2)Arte/Orl |
| Alternative name | C57BL/6NTac-Ccr2tm2982(T2A-Cre/ESR1-T2A-mKate2)Art |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Ccr2tm1(cre/ERT2, mKate2)Arte |
| Gene/Transgene symbol | Ccr2 |
Information from provider
| Provider | Burkhard Becher |
| Provider affiliation | University of Zurich |
| Genetic information | Ccr2-CreERT2-mKate2: This strain contains the ORF of CreERT2 and mKate2 knocked into the endogenous murine Ccr2 locus. Ensembl gene ID: ENSMUSG00000049103 |
| Phenotypic information | Homozygous:Animals are viable and fertile, no phenotypic difference to C57BL/6 mice.Heterozygous:Animals are viable and fertile, no phenotypic difference to C57BL/6 mice. |
| Breeding history | The mice have been bred in our facility for many generations and more than 100 animals were born. Heterozygous and homozygous mice are viable and fertile. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6N Tac |
Literature references
- The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity.;Croxford Andrew L, Lanzinger Margit, Hartmann Felix J, Schreiner Bettina, Mair Florian, Pelczar Pawel, Clausen Björn E, Jung Steffen, Greter Melanie, Becher Burkhard, ;2015;Immunity;43;502-14; 26341401