STOCK Whrnwi/H

Status

Available to order

EMMA IDEM:01296
International strain nameSTOCK Whrnwi/H
Alternative namewi
Strain typeSpontaneous
Allele/Transgene symbolWhrnwi,
Gene/Transgene symbolWhrn

Information from provider

ProviderPhilomena Mburu
Provider affiliationMRC Mammalian Genetics Unit
Phenotypic informationHomozygotes are deaf, show head tossing, circling and pale agouti colour. Heterozygotes and wild-type are both hearing and do not head toss or circle.
References
  • Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.;Mburu Philomena, Mustapha Mirna, Varela Anabel, Weil Dominique, El-Amraoui Aziz, Holme Ralph H, Rump Andreas, Hardisty Rachel E, Blanchard Stéphane, Coimbra Roney S, Perfettini Isabelle, Parkinson Nick, Mallon Ann-Marie, Glenister Pete, Rogers Mike J, Paige Adam J, Moir Lee, Clay Jo, Rosenthal Andre, Liu Xue Zhong, Blanco Gonzalo, Steel Karen P, Petit Christine, Brown Steve D M, ;2003;Nature genetics;34;421-8; 12833159

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal cochlear inner hair cell morphology / MGI
  • short inner hair cell stereocilia / MGI
  • circling / MGI
  • head bobbing / MGI
  • impaired righting response / MGI
  • deafness / MGI
  • absent cochlear microphonics / MGI
  • absent cochlear nerve compound action potential / MGI
  • short vestibular hair cell stereocilia / MGI
  • short cochlear hair cell stereocilia / MGI
  • abnormal outer hair cell stereociliary bundle morphology / MGI
  • abnormal auditory summating potential / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • decreased leukocyte cell number / MGI
  • enlarged adrenal glands / MGI
  • decreased body weight / MGI
  • abnormal maternal nurturing / MGI
  • hyperactivity / MGI
  • abnormal gait / MGI
  • impaired swimming / MGI
  • increased circulating corticosterone level / MGI
  • increased heart weight / MGI
  • increased liver weight / MGI
  • increased kidney weight / MGI
  • cochlear hair cell degeneration / MGI
  • cochlear inner hair cell degeneration / MGI
  • abnormal cochlear outer hair cell morphology / MGI
  • cochlear outer hair cell degeneration / MGI
  • abnormal cochlear hair cell stereociliary bundle morphology / MGI
  • decreased outer hair cell stereocilia number / MGI
  • short outer hair cell stereocilia / MGI
  • decreased uterus weight / MGI
  • decreased seminal vesicle weight / MGI
  • decreased thymus weight / MGI
  • increased oxygen consumption / MGI
  • head tossing / MGI
  • decreased glycogen level / MGI
  • decreased circulating glucose level / MGI
  • decreased total body fat amount / MGI

Literature references

  • Defects in whirlin, a PDZ domain molecule involved in stereocilia elongation, cause deafness in the whirler mouse and families with DFNB31.;Mburu Philomena, Mustapha Mirna, Varela Anabel, Weil Dominique, El-Amraoui Aziz, Holme Ralph H, Rump Andreas, Hardisty Rachel E, Blanchard Stéphane, Coimbra Roney S, Perfettini Isabelle, Parkinson Nick, Mallon Ann-Marie, Glenister Pete, Rogers Mike J, Paige Adam J, Moir Lee, Clay Jo, Rosenthal Andre, Liu Xue Zhong, Blanco Gonzalo, Steel Karen P, Petit Christine, Brown Steve D M, ;2003;Nature genetics;34;421-8; 12833159

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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