R26-rtTAtg/0:tetO-Cpt1atg/0 (R26rtTA-CPT1A)
Status | Available to order |
EMMA ID | EM:13349 |
International strain name | R26-rtTAtg/0:tetO-Cpt1atg/0 (R26rtTA-CPT1A) |
Alternative name | R26-rtTAtg/0:tetO-Cpt1atg/0 (R26rtTA-CPT1A) |
Strain type | Transgenic Strains |
Allele/Transgene symbol | TRE-CPT1A |
Gene/Transgene symbol | Tg(tetO-Cpt1a,-EGFP) |
Information from provider
Provider | Santiago Lamas |
Provider affiliation | Procesos Fisiológicos y Patológicos, Centro de Biología Molecular Severo Ochoa |
Genetic information | R26-rtTA cassette (Rosa 26 locus): ubiquitous expression of rtTA. TRE-CPT1A-P2A-GFP cassette (Col1a1 locus): CPT1A and GFP coding sequence under the control of the TRE element. P2A allows the protein excision among CPT1A and GFP. |
Phenotypic information | Homozygous:Phenotypically undistinguishable from wild-type mice. No anatomical anomalies, physiological variations, behavioural abnormalities or food uptake alterations. Heterozygous:No phenotypic alterations. Mice present a CPT1A overexpression and enhanced fatty acid oxidation ubiquitous. |
Breeding history | R26-rtTA: tetO-CPT1A mice (B6N;129Sv background) were backcrossed to C57BL/6J mice for at least 5 generations to generate this congenic strain. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | heterozygous C57BL/6J |
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