B10.Cg-Ncf1m1J H2q/Kctt
Status | Available to order |
EMMA ID | EM:01353 |
International strain name | B10.Cg-Ncf1m1J H2q/Kctt |
Alternative name | RHo-7 |
Strain type | Other |
Allele/Transgene symbol | H2q, |
Gene/Transgene symbol | H2 |
Information from provider
Provider | Rikard Holmdahl |
Provider affiliation | Lund University, CMB, Section for medical inflammation reseach |
Genetic information | The strain lacks expression of Ncf1 when homozygous for the mutation. The strain is based on The Jackson Laboratory's strain B6.Cg-Dock7m +/+ Leprdb/J (JAX stock ID 000697). However, this strain lacks the Lepr mutation, and basically only the Ncf1 gene remains from the original strain (minimal fragment). It is also backcrossed to C57BL/10.Q to a pure background (speed congenics). |
Phenotypic information | None. |
Breeding history | Backcrossed to B10.Q for more than 10 generations by speed congenics. |
References |
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Information from EMMA
Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Stage of embryos | 2-cell |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Chronic granulomatous disease / Orphanet_379
MGI phenotypes (allele matching)
Literature references
- Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.;Hultqvist Malin, Olofsson Peter, Holmberg Jens, Bäckström B Thomas, Tordsson Jesper, Holmdahl Rikard, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;12646-51; 15310853
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