C57BL/6N-Mettm2(MET*)Tcre/Cnrm
| Status | Available to order |
| EMMA ID | EM:13663 |
| International strain name | C57BL/6N-Mettm2(MET*)Tcre/Cnrm |
| Alternative name | Ex14Del-ki |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Mettm2(MET*)Tcre, |
| Gene/Transgene symbol | Met |
Information from provider
| Provider | PAOLO COMOGLIO |
| Provider affiliation | IFOM - Istituto FIRC di Oncologia Molecolare |
| Additional owner | Tiziana Crepaldi, Ph.D., Department of Oncology, University of Turin, Candiolo Cancer Institute, Candiolo (Torino) ITALY |
| Genetic information | Ex14Del-ki mice harbour the "humanized" knock-in mutation of the human MET allele without exon 14, which replaces the mouse Met gene. The coding region of exon 3 plus partial intron 3 was replaced with the mutant human MET CDS without exon 14 (NM_000245.4; 4032 bp). C57BL/6N ES cells were used for gene targeting. |
| Phenotypic information | Homozygous:not knownHeterozygous:Mice heterozygous for the Ex14Del-ki allele are viable and fertile. |
| Breeding history | The Ex14Del-ki mice were bred with C57BL/6N to generate the heterozygous mice. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Pediatric hepatocellular carcinoma / Orphanet_33402
- Papillary renal cell carcinoma / Orphanet_319298
- Osteofibrous dysplasia / Orphanet_488265
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
- Hereditary papillary renal cell carcinoma / Orphanet_47044