C57BL/6-Tg(Prox1-cre/ERT2)1Tmak/H
Status | Available to order |
EMMA ID | EM:13737 |
International strain name | C57BL/6-Tg(Prox1-cre/ERT2)1Tmak/H |
Alternative name | Prox1-CreERT2 |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(Prox1-cre/ERT2)1Tmak, |
Gene/Transgene symbol | Tg(Prox1-cre/ERT2)1Tmak |
Information from provider
Provider | Taija Makinen |
Provider affiliation | Lymphatic Development Laboratory, Uppsala University |
Genetic information | A cDNA encoding tamoxifen inducible Cre recombinase (CreERT2) followed by SV40 polyadenylation signal was introduced into the start codon of Prox1 in BAC clone RP23-190F21 using homologous recombination in bacteria. |
Phenotypic information | Homozygous:Phenotypically normalHeterozygous:Phenotypically normal |
Breeding history | Congenic |
References |
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Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice.;Bazigou Eleni, Lyons Oliver T A, Smith Alberto, Venn Graham E, Cope Celia, Brown Nigel A, Makinen Taija, ;2011;The Journal of clinical investigation;121;2984-92; 21765212
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