IMPC phenotypes (allele matching)
C57BL/6N-Atm1Brd Rasal2tm1a(EUCOMM)Wtsi Atp2b2Tkh/WtsiH[cc]
| Status | Available to order |
| EMMA ID | EM:13790 |
| International strain name | C57BL/6N-Atm1Brd Rasal2tm1a(EUCOMM)Wtsi Atp2b2Tkh/WtsiH[cc] |
| Alternative name | Tikho, Atp2b2-Tkh |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Rasal2tm1a(EUCOMM)Wtsi, |
| Gene/Transgene symbol | Rasal2 |
Information from provider
| Provider | Karen Steel |
| Provider affiliation | King |
| Genetic information | A missense mutation in the Atp2b2 gene, g.6:113759212G>C, causing an amino acid change of p.(Arg969Gly) (ENSMUST00000101045). |
| Phenotypic information | Homozygous:Mice homozygous for this allele exhibited rapidly progressive hearing loss.Heterozygous:Heterozygotes displayed slower progressive hearing loss, with the high frequencies affected first. |
| Breeding history | Bred for several years within a closed colony on a C57BL/6N background. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme.;Lewis Morag A, Ingham Neil J, Chen Jing, Pearson Selina, Di Domenico Francesca, Rekhi Sohinder, Allen Rochelle, Drake Matthew, Willaert Annelore, Rook Victoria, Pass Johanna, Keane Thomas, Adams David J, Tucker Abigail S, White Jacqueline K, Steel Karen P, ;2022;BMC biology;20;67; 35296311