C57BL/6N-Cdk6tm1c(EUCOMM)Wtsi/TcpBiat

Status

Available to order

EMMA IDEM:13810
International strain nameC57BL/6N-Cdk6tm1c(EUCOMM)Wtsi/TcpBiat
Alternative nameC57BL/6N-Cdk6/Tcp
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolCdk6tm1c(EUCOMM)Wtsi
Gene/Transgene symbolCdk6

Information from provider

ProviderVeronika Sexl
Provider affiliationDepartment of Biomedical Sciences, University of Veterinary Medicine
Genetic informationThe mouse line C57BL/6N-Cdk6tm1c(EUCOMM)Wtsi/Tcp (referred to as Cdk6fl/fl) was generated with C57BL/6N-Cdk6tm1a(EUCOMM)Wtsi/Tcp (available at the Canadian Mouse Mutant Repository (CMMR) at http://www.cmmr.ca/order.php?t=m&id=1766) made from EUCOMM ES cells (Bradley A, Anastassiadis K, Ayadi A, et al. The mammalian gene function resource: the International Knockout Mouse Consortium. Mamm Genome. 2012;23(9-10):580-586) at the Toronto Centre for Phenogenomics, Canada.
Phenotypic informationHomozygous:
No data available; no phenotype expected;

Heterozygous:
No data available; no phenotype expected;
Breeding historyFlp excision by breeding a heterozygous male C57BL/6N-Cdk6tm1a(EUCOMM)Wtsi/Tcp with heterozygous C57BL/6N-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Tcp female(s). The mouse line was established by backcrossing Cdk6tm1c+/-; Flp+/- mice to C57BL/6NCrl (less than 10 gen.).
References
  • Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system.;Maurer Barbara, Brandstoetter Tania, Kollmann Sebastian, Sexl Veronika, Prchal-Murphy Michaela, ;2021;Haematologica;106;2624-2632; 32855282
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivinghomozygous C57BL/6N

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Literature references

  • Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system.;Maurer Barbara, Brandstoetter Tania, Kollmann Sebastian, Sexl Veronika, Prchal-Murphy Michaela, ;2021;Haematologica;106;2624-2632; 32855282

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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