- decreased body length / IMPC
- decreased caudal vertebrae number / IMPC
- decreased circulating alkaline phosphatase level / IMPC
- abnormal bone structure / IMPC
- increased lean body mass / IMPC
- decreased lean body mass / IMPC
- increased total body fat amount / IMPC
- decreased total body fat amount / IMPC
- increased bone mineral content / IMPC
- decreased bone mineral content / IMPC
- preweaning lethality, complete penetrance / IMPC
- decreased food intake / IMPC
- decreased KLRG1+ CD8 alpha beta T cell number / IMPC
- abnormal epidermal immune compartment / IMPC
C57BL/6N-Cnot4tm1b(EUCOMM)Wtsi/WtsiCnbc
Status | Available to order |
EMMA ID | EM:14197 |
International strain name | C57BL/6N-Cnot4tm1b(EUCOMM)Wtsi/WtsiCnbc |
Alternative name | EPD0682_3_G11 |
Strain type | Targeted Mutant Strains |
Allele/Transgene symbol | Cnot4tm1b(EUCOMM)Wtsi, |
Gene/Transgene symbol | Cnot4 |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from EUCOMM ES clone EPD0682_3_G11. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele using a cell permeable HTN-Cre as described in doi:10.1007/s11248-013-9764-x. Click here for more information on EUCOMM final vectors. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
IMPC phenotypes (allele matching)
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