B6;CBA-Tg(Cyp1a1-cre)1Dwi/H
| Status | Available to order |
| EMMA ID | EM:14903 |
| International strain name | B6;CBA-Tg(Cyp1a1-cre)1Dwi/H |
| Alternative name | Tg(Cyp1a1-cre)1Dwi -Published as (AhCre) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Cyp1a1-cre)1Dwi, |
| Gene/Transgene symbol | Tg(Cyp1a1-cre)1Dwi |
Information from provider
| Provider | Douglas Winton |
| Provider affiliation | Cancer Research UK Cambridge Institute, University of Cambridge |
| Genetic information | An AhCre transgene vector, containing the cre coding sequence under the rat CYP1A1 promoter, was injected into fertilized CBAxC57BL/6 oocytes. Founder mice were backcrossed onto C57BL/6 mice to establish transgenic lines. Heterozygous transgenic lines were interbred to establish homozygous AhCre mice. |
| Phenotypic information | Homozygous:None breeds to homozygosityHeterozygous:No phenotype |
| Breeding history | The line was cryopreserved many years ago. It was created around 2002/3 by pronuclear injection of B6-CBA embryos and maintained as pairs of trios mainly comprised of transgenic males crossed to wildtype females. Initial wildtype breeders were B6. But the line is not congenic to B6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.;Ireland Heather, Kemp Richard, Houghton Carol, Howard Louise, Clarke Alan R, Sansom Owen J, Winton Douglas J, ;2004;Gastroenterology;126;1236-46; 15131783
- Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity.;Kemp Richard, Ireland Heather, Clayton Elizabeth, Houghton Carol, Howard Louise, Winton Douglas J, ;2004;Nucleic acids research;32;e92; 15247325