B6.Cg-Tg(Bmx-cre/ERT2)1Rha/H
| Status | Available to order |
| EMMA ID | EM:15026 |
| International strain name | B6.Cg-Tg(Bmx-cre/ERT2)1Rha/H |
| Alternative name | C57BL/6J-Tg(Bmx-cre/ERT2)1Rha |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Bmx-cre/ERT2)1Rha |
| Gene/Transgene symbol | Tg(Bmx-cre/ERT2)1Rha |
Information from provider
| Provider | Ralph H Adams |
| Provider affiliation | Max Planck Institute for Molecular Biomedicine |
| Genetic information | An inducible cre deleter under the control of the BMX non-receptor tyrosine kinase promoter; cre recombination is inducible via administration of tamoxifen. Useful for study of angiogenesis, atherosclerosis and neovascularization. Non-induced Bmx-CreERT2 mice demonstrate no cre recombinase activity, while tamoxifen-induced Bmx-CreERT2 mice demonstrate high levels of recombinase-mediated gene deletion in endothelial cells (95%+). |
| Phenotypic information | Homozygous:Not knownHeterozygous:Normal appearance |
| Breeding history | Founder lines were backcrossed to C57BL/6 for at least five generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Notch controls retinal blood vessel maturation and quiescence.;Ehling Manuel, Adams Susanne, Benedito Rui, Adams Ralf H, ;2013;Development (Cambridge, England);140;3051-61; 23785053