C57BL/6N-Eif2b5tm1c(EUCOMM)Wtsi/IcsOrl
Status | Available to order |
EMMA ID | EM:15095 |
International strain name | C57BL/6N-Eif2b5tm1c(EUCOMM)Wtsi/IcsOrl |
Alternative name | Eif2b5 |
Strain type | Targeted Mutant Strains : Conditional mutation |
Allele/Transgene symbol | Eif2b5tm1c(EUCOMM)Wtsi |
Gene/Transgene symbol | Eif2b5 |
Information from provider
Provider | Cécile FREMOND |
Provider affiliation | CNRS-TAAM-UAR44 |
Genetic information | This mouse line originates from EUCOMM ES clone EPD0116_1_C09. For further details on the construction of this clone see the page at a href=https://www.mousephenotype.org/data/alleles/MGI:2446176/tm1a(E UCOMM)Wtsi target=_blankthe IMPC portal/a. |
Phenotypic information | Homozygous:Homozygous mice have not been generated.Heterozygous:Heterozygous mice are currently being generated. |
Breeding history | Rederived mice carrying the tm1a mutation Eif2b5tm1a(EUCOMM)Wtsi, were crossed with the Flp recombinase expressing strain "C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics" (EM:05490) to obtain mice carrying the Eif2b5tm1c(EUCOMM)Wtsi converted allele. |
References | None available |
Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Congenital or early infantile CACH syndrome / Orphanet_157713
- Late infantile CACH syndrome / Orphanet_157716
- Ovarioleukodystrophy / Orphanet_99853
- Juvenile or adult CACH syndrome / Orphanet_157719
- Cree leukoencephalopathy / Orphanet_99854
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