- decreased level of surface class I molecules / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- decreased IgG level / MGI
- abnormal pancreas morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased IgM level / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- decreased circulating serum albumin level / MGI
- increased T-helper 1 cell number / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased susceptibility to infection induced morbidity/mortality / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal T cell number / MGI
- insulitis / MGI
- abnormal neuron proliferation / MGI
- abnormal immune system morphology / MGI
- abnormal spleen morphology / MGI
- abnormal immune system cell morphology / MGI
- postnatal growth retardation / MGI
- abnormal immune system physiology / MGI
- reduced fertility / MGI
- abnormal spleen periarteriolar lymphoid sheath morphology / MGI
- abnormal spleen marginal zone morphology / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- abnormal T cell physiology / MGI
- abnormal B cell physiology / MGI
- abnormal immune system organ morphology / MGI
- abnormal cytokine secretion / MGI
- decreased susceptibility to parasitic infection / MGI
- increased susceptibility to parasitic infection / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- abnormal spleen B cell follicle morphology / MGI
- absent spleen germinal center / MGI
- decreased IgG1 level / MGI
- abnormal lymph node cell ratio / MGI
NOD.129-Rag1tm1Bal B2mtm1Unc H2-Ab1tm1Doi/Orl
Status | Available to order |
EMMA ID | EM:01638 |
International strain name | NOD.129-Rag1tm1Bal B2mtm1Unc H2-Ab1tm1Doi/Orl |
Alternative name | NOD-IAbeta-beta2m-RAG1-/- |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Rag1tm1Bal, |
Gene/Transgene symbol | Rag1 |
Information from provider
Provider | Francoise Lepault |
Provider affiliation | INSERM U561 - Hopital Saint Vincent de Paul |
Genetic information | NOD mice deficient for IAbeta (H2-Ab1), beta-2 microglobulin (B2m) and Rag1 molecules. |
Phenotypic information | These mice have no T, B, NKT lymphocytes and no MHC molecules. Do not develop diabetes. Breeding more difficult than with wild-type mice. |
Breeding history | NOD mice deficient for IAbeta were crossed with NOD mice deficient for beta2m to generate NOD mice deficient for both molecules. The latter mice were then crossed with NOD mice deficient for Rag1. The three NOD knock-out strains were used after 10 backcrosses to the NOD background. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Severe combined immunodeficiency due to complete RAG1/2 deficiency / Orphanet_331206
- Combined immunodeficiency due to partial RAG1 deficiency / Orphanet_231154
- Omenn syndrome / Orphanet_39041
- Combined immunodeficiency with granulomatosis / Orphanet_157949
- Immunodeficiency by defective expression of MHC class I / Orphanet_34592
- Variant ABeta2M amyloidosis / Orphanet_314652
MGI phenotypes (allele matching)
Literature references
- Mice lacking MHC class II molecules.;Cosgrove D, Gray D, Dierich A, Kaufman J, Lemeur M, Benoist C, Mathis D, ;1991;Cell;66;1051-66; 1909605
- Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice.;Katz J, Benoist C, Mathis D, ;1993;European journal of immunology;23;3358-60; 8258349
- RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination.;Oettinger M A, Schatz D G, Gorka C, Baltimore D, ;1990;Science (New York, N.Y.);248;1517-23; 2360047
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