NOD.Cg-(D1Mit15-D1Mit359)C57BL/6J Cd1d1tm1Luc/Orl

Status

Available to order

EMMA IDEM:01648
International strain nameNOD.Cg-(D1Mit15-D1Mit359)C57BL/6J Cd1d1tm1Luc/Orl
Alternative nameNOD.B6-L2.CD1d-/-
Strain typeSpontaneous
Allele/Transgene symbolStia1C57BL/6J,
Gene/Transgene symbolStia1

Information from provider

ProviderAndré Herbelin
Provider affiliationGEM 2358, CNRS (Centre National de la Recherche Scientifique)
Genetic informationNOD congenic strain with the distal chromosome 1 from C57BL/6 line 2 and Cd1d knock-out mutation.
Phenotypic informationThis line bears the main QTL controlling serum levels of IgG1 and IG2b in NOD mice. The same interval also controls severity of experimental arthritis, number and function of invariant natural killer T (iNKT) cells, IgE serum levels and increase in resistance to endotoxinic shock.
Breeding history20 generations of backcross followed by sister-brother matings. Selection of subcongenics by additional backcrosses.
References
  • Genetic influences on the end-stage effector phase of arthritis.;Ji H, Gauguier D, Ohmura K, Gonzalez A, Duchatelle V, Danoy P, Garchon H J, Degott C, Lathrop M, Benoist C, Mathis D, ;2001;The Journal of experimental medicine;194;321-30; 11489951
  • Defective Fc gamma RII gene expression in macrophages of NOD mice: genetic linkage with up-regulation of IgG1 and IgG2b in serum.;Luan J J, Monteiro R C, Sautès C, Fluteau G, Eloy L, Fridman W H, Bach J F, Garchon H J, ;1996;Journal of immunology (Baltimore, Md. : 1950);157;4707-16; 8906852
  • Genetic control of NKT cell numbers maps to major diabetes and lupus loci.;Esteban Luis M, Tsoutsman Tatiana, Jordan Margaret A, Roach Daniel, Poulton Lynn D, Brooks Andrew, Naidenko Olga V, Sidobre Stephane, Godfrey Dale I, Baxter Alan G, ;2003;Journal of immunology (Baltimore, Md. : 1950);171;2873-8; 12960309

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • autoimmune response / MGI
  • decreased regulatory T cell number / MGI
  • kidney inflammation / MGI
  • glomerulonephritis / MGI
  • increased urine protein level / MGI
  • renal interstitial fibrosis / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • glomerulosclerosis / MGI
  • increased blood urea nitrogen level / MGI
  • increased IgG3 level / MGI
  • decreased interleukin-4 secretion / MGI
  • renal tubule atrophy / MGI
  • glomerular crescent / MGI
  • abnormal liver morphology / MGI
  • arrested T cell differentiation / MGI
  • decreased acute inflammation / MGI
  • decreased NK T cell number / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • decreased physiological sensitivity to xenobiotic / MGI

Literature references

  • Genetic influences on the end-stage effector phase of arthritis.;Ji H, Gauguier D, Ohmura K, Gonzalez A, Duchatelle V, Danoy P, Garchon H J, Degott C, Lathrop M, Benoist C, Mathis D, ;2001;The Journal of experimental medicine;194;321-30; 11489951
  • Defective Fc gamma RII gene expression in macrophages of NOD mice: genetic linkage with up-regulation of IgG1 and IgG2b in serum.;Luan J J, Monteiro R C, Sautès C, Fluteau G, Eloy L, Fridman W H, Bach J F, Garchon H J, ;1996;Journal of immunology (Baltimore, Md. : 1950);157;4707-16; 8906852
  • Genetic control of NKT cell numbers maps to major diabetes and lupus loci.;Esteban Luis M, Tsoutsman Tatiana, Jordan Margaret A, Roach Daniel, Poulton Lynn D, Brooks Andrew, Naidenko Olga V, Sidobre Stephane, Godfrey Dale I, Baxter Alan G, ;2003;Journal of immunology (Baltimore, Md. : 1950);171;2873-8; 12960309

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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