C3H.C-Zic2Ku/H

Status

Available to order

EMMA IDEM:01725
International strain nameC3H.C-Zic2Ku/H
Alternative nameKumba, GENA29
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolZic2Ku,
Gene/Transgene symbolZic2

Information from provider

ProviderRuth Arkell
Provider affiliationMRC Mammalian Genetics Unit
Genetic informationThe point mutation was identified as an A to T transversion at nucleotide 1350 of Zic2 (zinc finger domain-encoding sequence).
Phenotypic informationRare neural tube defects (approx. 1% of mice born with delayed posterior neural tube closure) or tail kink and ventral spotting in heterozygotes. Mutation maintained by backcrosses to C3H. The C3H background seems to decrease the penetrance of the visible heterozygous phenotypes. Mid-gestational lethality, with embryos exhibiting neural tube and other defects in homozygotes.
References
  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C3H/HeH
Breeding at archiving centreArchived as 2-cell embryos produced by IVF, using a heterozygous sperm donor congenic on a C3H/HeH genetic background, and wild-type C3H/HeH female oocyte donors.
Stage of embryos2-cell

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • belly spot / MGI
  • kinked tail / MGI
  • curly tail / MGI
  • spina bifida / MGI
  • exencephaly / MGI
  • incomplete rostral neuropore closure / MGI
  • abnormal eye distance/ position / MGI
  • abnormal notochord morphology / MGI
  • abnormal forebrain development / MGI
  • increased ectoderm apoptosis / MGI
  • abnormal primitive node morphology / MGI
  • abnormal prechordal plate morphology / MGI
  • holoprosencephaly / MGI
  • cyclopia / MGI
  • ocular hypotelorism / MGI
  • proboscis / MGI
  • hematoma / MGI
  • decreased neural crest cell number / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • delayed caudal neuropore closure / MGI
  • decreased rhombomere 3 size / MGI
  • decreased rhombomere 5 size / MGI
  • rostral body truncation / MGI

Literature references

  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
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Material Transfer Agreement (MTA)
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