B6;FVB-Tg(Slc6a3-icre)1Fto/Orl
| Status | Available to order |
| EMMA ID | EM:01738 |
| International strain name | B6;FVB-Tg(Slc6a3-icre)1Fto/Orl |
| Alternative name | C57BL/6.BAC-DATCre |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Slc6a3-icre)1Fto, |
| Gene/Transgene symbol | Tg(Slc6a3-icre)1Fto |
Information from provider
| Provider | François Tronche |
| Provider affiliation | GEM 2358, CNRS (Centre National de la Recherche Scientifique) |
| Genetic information | The expression of cre recombinase (icre version) is targeted to dopaminergic neurons using a bacterial artificial chromosome (BAC) encompassing the dopamine transporter gene (Slc6a3 or DAT). The expression profile has been checked by immunofluorescence. The cre expression is restricted to DAT-positive neurons. The efficiency of recombination has been analysed for several loxP-containing targets (GRlox, Gt(ROSA)26Sor-lacZ reporter strain) in F. Tronche's laboratory (Paris). In adult animals, recombination can be observed in all dopaminergic neurons and appears to be restricted to these neurons. |
| Phenotypic information | No defects observed. |
| Breeding history | F0 FVB/N mice were backcrossed for four generations to C57BL/6. |
| References |
|
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Literature references
- Analysis of dopamine transporter gene expression pattern -- generation of DAT-iCre transgenic mice.;Turiault Marc, Parnaudeau Sébastien, Milet Aude, Parlato Rosanna, Rouzeau Jean-Denis, Lazar Monique, Tronche François, ;2007;The FEBS journal;274;3568-3577; 17565601