B6.129-Cd247tm1Lov Fcer1gtm1Rav Rag1tm1Mom Tyrobptm1.1Viv/Orl

Status

Available to order

EMMA IDEM:01790
International strain nameB6.129-Cd247tm1Lov Fcer1gtm1Rav Rag1tm1Mom Tyrobptm1.1Viv/Orl
Alternative nameZGKR
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolRag1tm1Mom,
Gene/Transgene symbolRag1

Information from provider

ProviderElena Tomasello
Provider affiliationU136, CIML
Genetic informationCD3zeta (Cd247), FcRg (Fcer1g) and Rag1 gene expression has been completely inactivated by homologous recombination. DAP12 (Tyrobp) gene presents a loss-of-function mutation.
Phenotypic informationDeficiency in natural killer cell function.
Breeding history8 backcrosses to C57BL/6.
References
  • Multiplicity and plasticity of natural killer cell signaling pathways.;Chiesa Sabrina, Mingueneau Michael, Fuseri Nicolas, Malissen Bernard, Raulet David H, Malissen Marie, Vivier Eric, Tomasello Elena, ;2006;Blood;107;2364-72; 16291591

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • reduced long term depression / MGI
  • abnormal long term depression / MGI
  • enhanced long term potentiation / MGI
  • abnormal lateral geniculate nucleus morphology / MGI
  • enlarged lateral ventricles / MGI
  • decreased thymocyte number / MGI
  • abnormal superior colliculus morphology / MGI
  • absent long term depression / MGI
  • abnormal brain morphology / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal T-helper 1 cell morphology / MGI
  • abnormal excitatory postsynaptic potential / MGI
  • decreased double-positive T cell number / MGI
  • abnormal T-helper 1 physiology / MGI
  • decreased CD4-positive, alpha beta T cell number / MGI
  • abnormal single-positive T cell number / MGI
  • absent gamma-delta intraepithelial T cell / MGI
  • immune system phenotype / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interleukin-1 beta secretion / MGI
  • decreased interleukin-10 secretion / MGI
  • decreased interleukin-12b secretion / MGI
  • decreased interleukin-23 secretion / MGI
  • decreased interleukin-6 secretion / MGI
  • abnormal hemoglobin / MGI
  • increased susceptibility to parasitic infection / MGI
  • skeleton phenotype / MGI
  • hematoma / MGI
  • decreased platelet aggregation / MGI
  • impaired macrophage phagocytosis / MGI
  • abnormal immune cell physiology / MGI
  • abnormal mast cell physiology / MGI
  • abnormal dendritic cell antigen presentation / MGI
  • abnormal immunoglobulin level / MGI
  • increased IgE level / MGI
  • decreased myocardial infarction size / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • decreased platelet calcium level / MGI
  • decreased susceptibility to type I hypersensitivity reaction / MGI
  • abnormal platelet activation / MGI
  • abnormal NK cell physiology / MGI
  • increased granulocyte number / MGI
  • spleen hypoplasia / MGI
  • decreased immunoglobulin level / MGI
  • abnormal level of surface class II molecules / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • increased macrophage cell number / MGI
  • increased NK cell number / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • decreased mature B cell number / MGI
  • increased immature B cell number / MGI
  • scaly skin / MGI
  • dermatitis / MGI
  • thick skin / MGI
  • epidermal hyperplasia / MGI
  • mixed cellular infiltration to dermis / MGI
  • decreased IgM level / MGI
  • ear inflammation / MGI
  • decreased vascular permeability / MGI
  • increased eosinophil cell number / MGI
  • decreased neutrophil cell number / MGI
  • abnormal retina morphology / MGI
  • autoimmune response / MGI
  • abnormal lymphatic vessel morphology / MGI
  • abnormal coat/hair pigmentation / MGI
  • abnormal eye morphology / MGI
  • abnormal skin pigmentation / MGI
  • abnormal respiratory system morphology / MGI
  • abnormal response to infection / MGI
  • decreased susceptibility to induced colitis / MGI
  • thymus hypoplasia / MGI
  • abnormal B cell differentiation / MGI
  • abnormal T cell differentiation / MGI
  • abnormal inguinal lymph node morphology / MGI
  • nervous system phenotype / MGI
  • behavior/neurological phenotype / MGI
  • abnormal T cell morphology / MGI
  • absent mature B cells / MGI
  • abnormal T cell receptor V(D)J recombination / MGI
  • abnormal immunoglobulin V(D)J recombination / MGI
  • decreased inflammatory response / MGI
  • abnormal double-negative T cell morphology / MGI
  • abnormal thymus epithelium morphology / MGI
  • abnormal neuron proliferation / MGI
  • small thymus / MGI
  • decreased lymphocyte cell number / MGI
  • abnormal bone remodeling / MGI
  • increased bone mineral density / MGI
  • osteopetrosis / MGI
  • abnormal microglial cell morphology / MGI
  • abnormal myelination / MGI
  • abnormal osteoclast physiology / MGI
  • abnormal myelopoiesis / MGI
  • abnormal excitatory postsynaptic currents / MGI
  • decreased bone resorption / MGI
  • abnormal axon morphology / MGI
  • increased bone mass / MGI
  • abnormal bone ossification / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • increased bone mineral content / MGI
  • increased bone trabecula number / MGI
  • increased trabecular bone volume / MGI
  • failure of embryo implantation / MGI
  • reduced fertility / MGI
  • abnormal maternal decidual layer morphology / MGI
  • enlarged placenta / MGI
  • decreased uterine NK cell number / MGI
  • abnormal decidua basalis morphology / MGI
  • abnormal uterine spiral artery morphology / MGI
  • abnormal uterine spiral artery remodeling / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • increased dendritic cell number / MGI

Literature references

  • Multiplicity and plasticity of natural killer cell signaling pathways.;Chiesa Sabrina, Mingueneau Michael, Fuseri Nicolas, Malissen Bernard, Raulet David H, Malissen Marie, Vivier Eric, Tomasello Elena, ;2006;Blood;107;2364-72; 16291591

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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