NOD.129S6-Cd1d1tm1Luc/Orl

Status

Available to order

EMMA IDEM:01803
International strain nameNOD.129S6-Cd1d1tm1Luc/Orl
Alternative nameNOD CD1d KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolCd1d1tm1Luc,
Gene/Transgene symbolCd1d1

Information from provider

ProviderThieblemont Nathalie
Provider affiliationCNRS UMR 8147
Genetic informationA 200 bp sequence in the third exon of the Cd1d1 gene was replaced by a neomycin resistance cassette.
Phenotypic informationAbsence of natural killer T cells.
References
  • CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.;Mendiratta S K, Martin W D, Hong S, Boesteanu A, Joyce S, Van Kaer L, ;1997;Immunity;6;469-77; 9133426

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • autoimmune response / MGI
  • decreased regulatory T cell number / MGI
  • kidney inflammation / MGI
  • glomerulonephritis / MGI
  • increased urine protein level / MGI
  • renal interstitial fibrosis / MGI
  • increased anti-double stranded DNA antibody level / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • glomerulosclerosis / MGI
  • increased blood urea nitrogen level / MGI
  • increased IgG3 level / MGI
  • decreased interleukin-4 secretion / MGI
  • renal tubule atrophy / MGI
  • glomerular crescent / MGI
  • abnormal liver morphology / MGI
  • arrested T cell differentiation / MGI
  • decreased acute inflammation / MGI
  • decreased NK T cell number / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased interferon-gamma secretion / MGI
  • decreased physiological sensitivity to xenobiotic / MGI

Literature references

  • CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4.;Mendiratta S K, Martin W D, Hong S, Boesteanu A, Joyce S, Van Kaer L, ;1997;Immunity;6;469-77; 9133426

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).