B6.129S2-Otogtm1Prs/Orl

Status

Available to order

EMMA IDEM:01820
International strain nameB6.129S2-Otogtm1Prs/Orl
Alternative nameOtogC57BL/6J
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolOtogtm1Prs,
Gene/Transgene symbolOtog

Information from provider

ProviderSIMMLER MARIE-CHRISTINE
Provider affiliationInstitut Jacques-Monod, CNRS, Equipe labellisée INSERM U950
Genetic informationTo inactivate the Otog gene the first three exons were removed and replaced with the lacZ gene, fused in-frame with the Otog translation initiation codon.
Phenotypic informationIn Otog -/- mice, both vestibular and auditory functions were impaired.
References
  • Twister mutant mice are defective for otogelin, a component specific to inner ear acellular membranes;Simmler MC, Zwaenepoel I, Verpy E, Guillaud L, Elbaz C, Petit C, Panthier JJ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;960-6; 11063250
  • Targeted disruption of otog results in deafness and severe imbalance.;Simmler M C, Cohen-Salmon M, El-Amraoui A, Guillaud L, Benichou J C, Petit C, Panthier J J, ;2000;Nature genetics;24;139-43; 10655058

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
MGI phenotypes (allele matching)
  • abnormal cochlea morphology / MGI
  • circling / MGI
  • abnormal posture / MGI
  • impaired swimming / MGI
  • impaired righting response / MGI
  • impaired balance / MGI
  • abnormal semicircular canal morphology / MGI
  • detached otolithic membrane / MGI
  • abnormal tectorial membrane morphology / MGI
  • abnormal crista ampullaris morphology / MGI
  • head tilt / MGI
  • abnormal vestibular saccule morphology / MGI
  • abnormal utricle morphology / MGI
  • impaired hearing / MGI
  • absent pinna reflex / MGI
  • increased or absent threshold for auditory brainstem response / MGI

Literature references

  • Twister mutant mice are defective for otogelin, a component specific to inner ear acellular membranes;Simmler MC, Zwaenepoel I, Verpy E, Guillaud L, Elbaz C, Petit C, Panthier JJ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;960-6; 11063250
  • Targeted disruption of otog results in deafness and severe imbalance.;Simmler M C, Cohen-Salmon M, El-Amraoui A, Guillaud L, Benichou J C, Petit C, Panthier J J, ;2000;Nature genetics;24;139-43; 10655058

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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