C3;C-GckGena348/H
Status | Available to order |
EMMA ID | EM:01842 |
International strain name | C3;C-GckGena348/H |
Alternative name | Gck |
Strain type | Induced Mutant Strains : Chemically-induced |
Allele/Transgene symbol | GckGena348, |
Gene/Transgene symbol | Gck |
Information from provider
Provider | Roger Cox |
Provider affiliation | MRC Harwell, Didcot, Oxon |
Genetic information | Impaired glucose tolerance in males and females |
Phenotypic information | High blood glucose and increased body weight |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Hyperinsulinism due to glucokinase deficiency / Orphanet_79299
- MODY / Orphanet_552
- Permanent neonatal diabetes mellitus / Orphanet_99885
MGI phenotypes (allele matching)
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
- A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene.;Toye Ayo A, Moir Lee, Hugill Alison, Bentley Liz, Quarterman Julie, Mijat Vesna, Hough Tertius, Goldsworthy Michelle, Haynes Alison, Hunter A Jacqueline, Browne Mick, Spurr Nigel, Cox Roger D, ;2004;Diabetes;53;1577-83; 15161764
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