C3;C-Snap25Bdr/H

Status

Available to order

EMMA IDEM:01844
International strain nameC3;C-Snap25Bdr/H
Alternative nameGENA70
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolSnap25Bdr,
Gene/Transgene symbolSnap25

Information from provider

ProviderPat Nolan
Provider affiliationMRC Mammalian Genetics Unit
Genetic informationPoint mutation resulting in a subtle ataxic gait from weaning age, 10-20% smaller than littermates
Phenotypic informationHomozygous mutants die at P1, heterozygous mutants show subtle ataxic gait from weaning age, 10-20% smaller than littermates
References
  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
  • A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.;Jeans Alexander F, Oliver Peter L, Johnson Reuben, Capogna Marco, Vikman Jenny, Molnár Zoltán, Babbs Arran, Partridge Christopher J, Salehi Albert, Bengtsson Martin, Eliasson Lena, Rorsman Patrik, Davies Kay E, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;2431-6; 17283335

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal motor capabilities/coordination/movement / MGI
  • ataxia / MGI
  • impaired coordination / MGI
  • decreased glucagon secretion / MGI
  • decreased insulin secretion / MGI
  • abnormal pancreatic beta cell physiology / MGI
  • decreased synaptic glutamate release / MGI
  • abnormal miniature excitatory postsynaptic currents / MGI
  • behavior/neurological phenotype / MGI
  • taste/olfaction phenotype / MGI
  • decreased prepulse inhibition / MGI

Literature references

  • A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
  • A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.;Jeans Alexander F, Oliver Peter L, Johnson Reuben, Capogna Marco, Vikman Jenny, Molnár Zoltán, Babbs Arran, Partridge Christopher J, Salehi Albert, Bengtsson Martin, Eliasson Lena, Rorsman Patrik, Davies Kay E, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;2431-6; 17283335

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).