- abnormal motor capabilities/coordination/movement / MGI
- ataxia / MGI
- impaired coordination / MGI
- decreased glucagon secretion / MGI
- decreased insulin secretion / MGI
- abnormal pancreatic beta cell physiology / MGI
- decreased synaptic glutamate release / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- behavior/neurological phenotype / MGI
- taste/olfaction phenotype / MGI
- decreased prepulse inhibition / MGI
C3;C-Snap25Bdr/H
Status | Available to order |
EMMA ID | EM:01844 |
International strain name | C3;C-Snap25Bdr/H |
Alternative name | GENA70 |
Strain type | Induced Mutant Strains : Chemically-induced |
Allele/Transgene symbol | Snap25Bdr, |
Gene/Transgene symbol | Snap25 |
Information from provider
Provider | Pat Nolan |
Provider affiliation | MRC Mammalian Genetics Unit |
Genetic information | Point mutation resulting in a subtle ataxic gait from weaning age, 10-20% smaller than littermates |
Phenotypic information | Homozygous mutants die at P1, heterozygous mutants show subtle ataxic gait from weaning age, 10-20% smaller than littermates |
References |
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Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Presynaptic congenital myasthenic syndromes / Orphanet_98914
MGI phenotypes (allele matching)
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191
- A dominant mutation in Snap25 causes impaired vesicle trafficking, sensorimotor gating, and ataxia in the blind-drunk mouse.;Jeans Alexander F, Oliver Peter L, Johnson Reuben, Capogna Marco, Vikman Jenny, Molnár Zoltán, Babbs Arran, Partridge Christopher J, Salehi Albert, Bengtsson Martin, Eliasson Lena, Rorsman Patrik, Davies Kay E, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;2431-6; 17283335
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