B6;CBACa-Tg(PMP22)C22Clh/H

Status

Available to order

EMMA IDEM:01883
International strain nameB6;CBACa-Tg(PMP22)C22Clh/H
Alternative nameTg(PMP22)C22Clh
Strain typeTransgenic Strains
Allele/Transgene symbolTg(PMP22)C22Clh,
Gene/Transgene symbolTg(PMP22)C22Clh

Information from provider

ProviderClare Huxley
Provider affiliationImperial College, London
Genetic informationYeast artificial chromosome carrying the intact human PMP22 gene. PMP22 is expressed in the peripheral nerves at about 1.7 times the level of the endogenous mouse Pmp22 mRNA.
Phenotypic informationHeterozygotes have thin myelin and reduced nerve conduction velocity causing shaky and unsteady gait.
References
  • Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA.;Huxley C, Passage E, Manson A, Putzu G, Figarella-Branger D, Pellissier J F, Fontés M, ;1996;Human molecular genetics;5;563-9; 8733121
  • Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice.;Huxley C, Passage E, Robertson A M, Youl B, Huston S, Manson A, Sabéran-Djoniedi D, Figarella-Branger D, Pellissier J F, Thomas P K, Fontés M, ;1998;Human molecular genetics;7;449-58; 9467003

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI allele-associated human disease models

Literature references

  • Construction of a mouse model of Charcot-Marie-Tooth disease type 1A by pronuclear injection of human YAC DNA.;Huxley C, Passage E, Manson A, Putzu G, Figarella-Branger D, Pellissier J F, Fontés M, ;1996;Human molecular genetics;5;563-9; 8733121
  • Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice.;Huxley C, Passage E, Robertson A M, Youl B, Huston S, Manson A, Sabéran-Djoniedi D, Figarella-Branger D, Pellissier J F, Thomas P K, Fontés M, ;1998;Human molecular genetics;7;449-58; 9467003

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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