C3HeB/FeJ-Jag1^Mhdahtu/Ieg

Status	Available to order
EMMA ID	EM:00199
International strain name	C3HeB/FeJ-Jag1^Mhdahtu/Ieg
Alternative name	ABE2
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Jag1^Mhdahtu,
Gene/Transgene symbol	Jag1

Information from provider

Provider	Martin Hrabe de Angelis
Provider affiliation	Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH)
Genetic information	ENU-induced mutation of Jag1. Strains EM:00199 and EM:04920 carry the same mutant allele. Strain EM:00199 has been backcrossed around 5 times to C3HeB/FeJ. Strain EM:04920 has possibly been further backcrossed 1/2 times to C3HeB/FeJ.
Phenotypic information	Head tossing.
Breeding history	Around 5 times backcrossed to C3HeB/FeJ.
References	Genome-wide, large-scale production of mutant mice by ENU mutagenesis.;Hrabé de Angelis M H, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R, ;2000;Nature genetics;25;444-7; 10932192 The Notch ligand Jagged1 is required for inner ear sensory development.;Kiernan A E, Ahituv N, Fuchs H, Balling R, Avraham K B, Steel K P, Hrabé de Angelis M, ;2001;Proceedings of the National Academy of Sciences of the United States of America;98;3873-8; 11259677 Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.;Fuchs H, Schughart K, Wolf E, Balling R, Hrabé de Angelis M, ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;528-30; 10886017

Information from EMMA

Archiving centre	Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI allele-associated human disease models

Alagille syndrome / DOID:9245

Orphanet associated rare diseases, based on orthologous gene matching

Tetralogy of Fallot / Orphanet_3303
Alagille syndrome due to a JAG1 point mutation / Orphanet_261619

MGI phenotypes (allele matching)

abnormal organ of Corti morphology / MGI
abnormal semicircular canal morphology / MGI
abnormal cochlear hair cell morphology / MGI
head shaking / MGI
abnormal crista ampullaris morphology / MGI
increased cochlear inner hair cell number / MGI
decreased cochlear outer hair cell number / MGI
head tossing / MGI
hearing/vestibular/ear phenotype / MGI
abnormal semicircular canal ampulla morphology / MGI
enlarged pericardium / MGI
abnormal blood vessel morphology / MGI
hemorrhage / MGI
abnormal vitelline vasculature morphology / MGI
kinked neural tube / MGI
embryonic growth retardation / MGI
embryonic lethality during organogenesis, complete penetrance / MGI
embryonic lethality during organogenesis / MGI
embryo tissue necrosis / MGI

Literature references

Genome-wide, large-scale production of mutant mice by ENU mutagenesis.;Hrabé de Angelis M H, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R, ;2000;Nature genetics;25;444-7; 10932192
The Notch ligand Jagged1 is required for inner ear sensory development.;Kiernan A E, Ahituv N, Fuchs H, Balling R, Avraham K B, Steel K P, Hrabé de Angelis M, ;2001;Proceedings of the National Academy of Sciences of the United States of America;98;3873-8; 11259677
Screening for dysmorphological abnormalities--a powerful tool to isolate new mouse mutants.;Fuchs H, Schughart K, Wolf E, Balling R, Hrabé de Angelis M, ;2000;Mammalian genome : official journal of the International Mammalian Genome Society;11;528-30; 10886017

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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C3HeB/FeJ-Jag1Mhdahtu/Ieg