MGI phenotypes (allele matching)
B6Rcc.129-Cd44tm1.1Ugu/Cnrm
| Status | Available to order |
| EMMA ID | EM:01994 |
| International strain name | B6Rcc.129-Cd44tm1.1Ugu/Cnrm |
| Alternative name | C57 BL/6RCC CD44v6v7-/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd44tm1.1Ugu, |
| Gene/Transgene symbol | Cd44 |
Information from provider
| Provider | Ursula Günthert |
| Provider affiliation | Institut für Pathologie, University of Basel |
| Genetic information | A loxP site was inserted 3' of exon v6 and a neomycin resistance cassette, with a 5' loxP site, was inserted 5' of exon v6 of the Cd44 gene. During insertion, 1.6 kb of sequence was lost in the exon v7 region; cre recombinase was transiently expressed in ES cells allowing the removal of neomycin cassette and exon v6. Mice lack both exon v6 and v7. |
| Phenotypic information | Cd44v6v7-/-: Strongly reduced symptoms in autoimmune diseases and haemopoiesis. |
| Breeding history | 10 generations backcrossed onto C57BL/6Rcc; currently bred as C57BL/6Rcc Cd44v6v7-/-. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).;Wittig B M, Johansson B, Zöller M, Schwärzler C, Günthert U, ;2000;The Journal of experimental medicine;191;2053-64; 10859330