MGI phenotypes (allele matching)
B6Rcc.129-Cd44tm1Ugu/Cnrm
| Status | Available to order |
| EMMA ID | EM:01995 |
| International strain name | B6Rcc.129-Cd44tm1Ugu/Cnrm |
| Alternative name | C57 BL/6RCC CD44v7-/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd44tm1Ugu, |
| Gene/Transgene symbol | Cd44 |
Information from provider
| Provider | Ursula Günthert |
| Provider affiliation | Institut für Pathologie, University of Basel |
| Genetic information | A loxP site was inserted 3' of exon v6 and a neomycin resistance cassette, with a 5' loxP site, was inserted 5' of exon v6 of the Cd44 gene. During insertion, 1.6 kb of sequence was lost in the exon v7 region leading to deficient expression of this variant in homozygous mutant mice (Cd44v7 -/-). |
| Phenotypic information | Cd44v7-/-: Strongly reduced symptoms in autoimmune diseases and haemopoiesis. |
| Breeding history | 10 generations backcrossed onto C57BL/6Rcc; currently bred as C57BL/6Rcc Cd44v7-/-. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).;Wittig B M, Johansson B, Zöller M, Schwärzler C, Günthert U, ;2000;The Journal of experimental medicine;191;2053-64; 10859330