B6Rcc.B6J-ApcMin/Cnrm

Status

Available to order

EMMA IDEM:02000
International strain nameB6Rcc.B6J-ApcMin/Cnrm
Alternative nameC57 BL/6RCC Min/+
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolApcMin,
Gene/Transgene symbolApc

Information from provider

ProviderUrsula Günthert
Provider affiliationInstitut für Pathologie, University of Basel
Genetic informationEthylnitrosurea induced mutation. A transversion point mutation in the Apc (adenomatosis polyposis coli) gene that alters nucleotide 2549 from a T to an A and converts codon 850 from leucine-encoding to a stop, generating the mutant allele ApcMin (adenomatosis polyposis coli; multiple intestinal neoplasia).
Phenotypic informationMin/+: development of early stages of colon carcinoma, polyps.
Breeding history10 generations backcrossed onto C57BL/6Rcc.
References
  • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.;Moser A R, Pitot H C, Dove W F, ;1990;Science (New York, N.Y.);247;322-4; 2296722

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal mammary gland development / MGI
  • abnormal ovarian folliculogenesis / MGI
  • abnormal ovarian follicle morphology / MGI
  • absent mature ovarian follicles / MGI
  • absent corpus luteum / MGI
  • abnormal vagina epithelium morphology / MGI
  • decreased body weight / MGI
  • increased incidence of induced tumors / MGI
  • ovary atrophy / MGI
  • uterus atrophy / MGI
  • reproductive system phenotype / MGI
  • adrenal gland hyperplasia / MGI
  • absent nipple / MGI
  • increased mammary gland tumor incidence / MGI
  • mammary gland hyperplasia / MGI
  • anemia / MGI
  • premature death / MGI
  • increased intestinal adenoma incidence / MGI
  • increased intestinal adenocarcinoma incidence / MGI
  • abnormal pregnancy / MGI
  • extended life span / MGI
  • aneuploidy / MGI
  • increased incidence of tumors by chemical induction / MGI
  • decreased intestinal adenoma incidence / MGI
  • decreased hematocrit / MGI
  • hyperlipidemia / MGI
  • melena / MGI
  • rectal prolapse / MGI
  • abnormal intestinal mucosa morphology / MGI
  • increased mammary adenocarcinoma incidence / MGI
  • intestinal obstruction / MGI
  • abnormal intestinal goblet cell morphology / MGI
  • abnormal large intestine crypts of Lieberkuhn morphology / MGI
  • intestine polyps / MGI
  • abnormal enterocyte proliferation / MGI
  • decreased T cell number / MGI
  • decreased NK cell number / MGI
  • decreased splenocyte number / MGI
  • neoplasm / MGI
  • increased circulating triglyceride level / MGI
  • increased circulating free fatty acid level / MGI
  • postnatal growth retardation / MGI
  • increased colonic adenoma incidence / MGI
  • hepatic steatosis / MGI
  • decreased macrophage cell number / MGI
  • increased prostaglandin level / MGI
  • abnormal embryo development / MGI
  • abnormal embryo size / MGI
  • abnormal egg cylinder morphology / MGI
  • abnormal cell physiology / MGI
  • embryonic lethality, complete penetrance / MGI
  • decreased embryo size / MGI
  • embryonic lethality between implantation and placentation / MGI
  • absent mandible / MGI
  • abnormal brain development / MGI
  • acrania / MGI
  • perinatal lethality, complete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • absent midbrain / MGI
  • absent forebrain / MGI

Literature references

  • A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.;Moser A R, Pitot H C, Dove W F, ;1990;Science (New York, N.Y.);247;322-4; 2296722

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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