CByIco.129-Cd44tm1.1Ugu/Ieg
Status | Available to order |
EMMA ID | EM:02019 |
International strain name | CByIco.129-Cd44tm1.1Ugu/Ieg |
Alternative name | BALB/cByJIco CD44v6v7-/- |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Cd44tm1.1Ugu, |
Gene/Transgene symbol | Cd44 |
Information from provider
Provider | Ursula Günthert |
Provider affiliation | Institut für Pathologie, University of Basel |
Genetic information | This allele was generated from the ES cell line used to produce Cd44tm1Ugu by transient cre recombinase expression in the ES cells prior to electroporation. In these mice, both exons v6 and v7 are removed or deficient. |
Phenotypic information | Cd44v6v7-/-: Strongly reduced symptoms in autoimmune diseases. |
Breeding history | Backcrossed for 10 generations; kept as homozygous strain on BALB/cByJIco background. |
References |
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Information from EMMA
Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).;Wittig B M, Johansson B, Zöller M, Schwärzler C, Günthert U, ;2000;The Journal of experimental medicine;191;2053-64; 10859330
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