D1.129-Cd44tm1Ugu/Orl
Status | Available to order |
EMMA ID | EM:02025 |
International strain name | D1.129-Cd44tm1Ugu/Orl |
Alternative name | DBA/1 CD44v7-/- |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Cd44tm1Ugu, |
Gene/Transgene symbol | Cd44 |
Information from provider
Provider | Ursula Günthert |
Provider affiliation | Institut für Pathologie, University of Basel |
Genetic information | A loxP site was inserted 3' of exon v6 and a neomycin resistance cassette, with a 5' loxP site, was inserted 5' of exon v6 of the Cd44 gene. During insertion, 1.6 kb of sequence was lost in the exon v7 region leading to deficient expression of this variant in homozygous mutant mice (Cd44v7 -/-). |
Phenotypic information | Cd44v7-/-: Strongly reduced symptoms in autoimmune diseases. |
Breeding history | The DBA/1 Cd44v7-/- strain was backcrossed for 10 generations onto the DBA/1 background and is kept as DBA/1 CD44v7-/-. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous , homozygous |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).;Wittig B M, Johansson B, Zöller M, Schwärzler C, Günthert U, ;2000;The Journal of experimental medicine;191;2053-64; 10859330
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