B6.129-Trp53inp1tm1Acar/Orl

Status

Available to order

EMMA IDEM:02038
International strain nameB6.129-Trp53inp1tm1Acar/Orl
Alternative nameTP53INP1 KO B6
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolTrp53inp1tm1Acar,
Gene/Transgene symbolTrp53inp1

Information from provider

ProviderAlice Carrier
Provider affiliationInserm U624
Genetic informationA null mutation was introduced in 129/Sv ES cells by replacing coding exons 2, 3 and 4 of Trp53inp1 gene with a neomycin resistance cassette. This cassette contains the neo gene and the gene encoding the cre recombinase designed for self-excision in male germline, flanked by loxP sites (Bunting M et al., Genes&Dev. 1999, 13/1524; Genbank AF169416).
Phenotypic informationNone.
Breeding historyMutation was introduced in 129/Sv ES cells, chimeric males were mated to C57BL/6 females to generate heterozygous pups on mixed 129/Sv x C57BL/6 background, then backcrossed on C57BL/6 background for 8 generations. The strain is currently bred on B6 background.
References
  • Molecular and functional characterization of the stress-induced protein (SIP) gene and its two transcripts generated by alternative splicing. SIP induced by stress and promotes cell death.;Tomasini R, Samir A A, Vaccaro M I, Pebusque M J, Dagorn J C, Iovanna J L, Dusetti N J, ;2001;The Journal of biological chemistry;276;44185-92; 11557757
  • p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis.;Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng C C, Taya Y, Monden M, Nakamura Y, ;2001;Molecular cell;8;85-94; 11511362
  • P53-dependent expression of the stress-induced protein (SIP).;Tomasini Richard, Samir Amina Azizi, Pebusque Marie-Josèphe, Calvo Ezequiel L, Totaro Serena, Dagorn Jean Charles, Dusetti Nelson J, Iovanna Juan L, ;2002;European journal of cell biology;81;294-301; 12067065
  • TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.;Tomasini Richard, Samir Amina Azizi, Carrier Alice, Isnardon Daniel, Cecchinelli Barbara, Soddu Silvia, Malissen Bernard, Dagorn Jean-Charles, Iovanna Juan L, Dusetti Nelson J, ;2003;The Journal of biological chemistry;278;37722-9; 12851404
  • Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer.;Jiang Pei-Hong, Motoo Yoshiharu, Garcia Stéphane, Iovanna Juan Lucio, Pébusque Marie-Josèphe, Sawabu Norio, ;2006;World journal of gastroenterology;12;691-6; 16521180
  • Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1.;Gommeaux Julien, Cano Carla, Garcia Stéphane, Gironella Meritxell, Pietri Sylvia, Culcasi Marcel, Pébusque Marie-Josèphe, Malissen Bernard, Dusetti Nelson, Iovanna Juan, Carrier Alice, ;2007;Molecular and cellular biology;27;2215-28; 17242209

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI allele-associated human disease models

MGI phenotypes (allele matching)
  • abnormal cell morphology / MGI
  • abnormal crypts of Lieberkuhn morphology / MGI
  • abnormal intestinal mucosa morphology / MGI
  • increased body weight / MGI
  • hyperglycemia / MGI
  • neoplasm / MGI
  • increased colonic adenoma incidence / MGI
  • increased circulating insulin level / MGI
  • hepatic steatosis / MGI
  • increased liver weight / MGI
  • large intestinal inflammation / MGI
  • oxidative stress / MGI
  • increased incidence of tumors by chemical induction / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • increased susceptibility to weight gain / MGI
  • increased susceptibility to diet-induced obesity / MGI
  • abnormal mitochondrion morphology / MGI
  • abnormal mitochondrial physiology / MGI
  • abnormal epididymal fat pad morphology / MGI
  • increased susceptibility to induced colitis / MGI
  • abnormal renal fat pad morphology / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal respiratory electron transport chain / MGI
  • abnormal oxidative phosphorylation / MGI
  • increased mitochondria number / MGI
  • abnormal mitophagy / MGI
  • increased body fat mass / MGI
  • increased susceptibility to diet-induced non-insulin dependent diabetes / MGI

Literature references

  • Molecular and functional characterization of the stress-induced protein (SIP) gene and its two transcripts generated by alternative splicing. SIP induced by stress and promotes cell death.;Tomasini R, Samir A A, Vaccaro M I, Pebusque M J, Dagorn J C, Iovanna J L, Dusetti N J, ;2001;The Journal of biological chemistry;276;44185-92; 11557757
  • p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis.;Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng C C, Taya Y, Monden M, Nakamura Y, ;2001;Molecular cell;8;85-94; 11511362
  • P53-dependent expression of the stress-induced protein (SIP).;Tomasini Richard, Samir Amina Azizi, Pebusque Marie-Josèphe, Calvo Ezequiel L, Totaro Serena, Dagorn Jean Charles, Dusetti Nelson J, Iovanna Juan L, ;2002;European journal of cell biology;81;294-301; 12067065
  • TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity.;Tomasini Richard, Samir Amina Azizi, Carrier Alice, Isnardon Daniel, Cecchinelli Barbara, Soddu Silvia, Malissen Bernard, Dagorn Jean-Charles, Iovanna Juan L, Dusetti Nelson J, ;2003;The Journal of biological chemistry;278;37722-9; 12851404
  • Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer.;Jiang Pei-Hong, Motoo Yoshiharu, Garcia Stéphane, Iovanna Juan Lucio, Pébusque Marie-Josèphe, Sawabu Norio, ;2006;World journal of gastroenterology;12;691-6; 16521180
  • Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1.;Gommeaux Julien, Cano Carla, Garcia Stéphane, Gironella Meritxell, Pietri Sylvia, Culcasi Marcel, Pébusque Marie-Josèphe, Malissen Bernard, Dusetti Nelson, Iovanna Juan, Carrier Alice, ;2007;Molecular and cellular biology;27;2215-28; 17242209

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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