129(B6)-Apoetm1Bres Plattm1Mlg/CljH[cc]

Status

Available to order

EMMA IDEM:02063
International strain name129(B6)-Apoetm1Bres Plattm1Mlg/CljH[cc]
Alternative nameApoE/tPA
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolPlattm1Mlg,
Gene/Transgene symbolPlat

Information from provider

ProviderChristopher Jackson
Provider affiliationUniversity of Bristol
Genetic informationTargeted null mutation of the apolipoprotein E and tissue plasminogen activator (Plat, or tPA) genes.
Phenotypic informationNone.
References
  • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
  • Studies of mice lacking plasminogen activator gene function suggest that plasmin production prior to ovulation exceeds the amount needed for optimal ovulation efficiency.;Ny A, Nordström L, Carmeliet P, Ny T, ;1997;European journal of biochemistry;244;487-93; 9119016

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal digestive system physiology / MGI
  • increased circulating cholesterol level / MGI
  • abnormal circulating cholesterol level / MGI
  • xanthoma / MGI
  • atherosclerotic lesions / MGI
  • abnormal circulating LDL cholesterol level / MGI
  • abnormal cerebral cortex morphology / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal neuron morphology / MGI
  • increased circulating VLDL cholesterol level / MGI
  • increased triglyceride level / MGI
  • increased susceptibility to atherosclerosis / MGI
  • decreased circulating HDL cholesterol level / MGI
  • increased circulating triglyceride level / MGI
  • decreased angiogenesis / MGI
  • altered response to CNS ischemic injury / MGI
  • abnormal microglial cell physiology / MGI
  • intracerebral hemorrhage / MGI
  • heart left ventricle hypertrophy / MGI
  • reduced thrombolysis / MGI
  • pulmonary interstitial fibrosis / MGI
  • decreased susceptibility to induced choroidal neovascularization / MGI
  • decreased susceptibility to induced retinal damage / MGI
  • abnormal thrombosis / MGI
  • growth/size/body region phenotype / MGI
  • immune system phenotype / MGI
  • reproductive system phenotype / MGI
  • increased macrophage cell number / MGI
  • decreased ventricle muscle contractility / MGI
  • cardiac interstitial fibrosis / MGI
  • decreased cerebral infarction size / MGI
  • abnormal acute phase protein level / MGI
  • mortality/aging / MGI
  • pulmonary alveolar hemorrhage / MGI
  • decreased retinal apoptosis / MGI
  • decreased anxiety-related response / MGI
  • decreased exploration in new environment / MGI
  • abnormal cued conditioning behavior / MGI
  • abnormal contextual conditioning behavior / MGI
  • reduced long term potentiation / MGI
  • increased circulating corticosterone level / MGI
  • absent long term depression / MGI
  • impaired synaptic plasticity / MGI
  • decreased vertical activity / MGI
  • abnormal active avoidance behavior / MGI
  • abnormal motor learning / MGI
  • chronic joint inflammation / MGI
  • joint swelling / MGI
  • arthritis / MGI
  • muscle phenotype / MGI
  • behavior/neurological phenotype / MGI
  • decreased dopamine level / MGI
  • abnormal cytokine level / MGI
  • impaired conditioned place preference behavior / MGI
  • impaired behavioral response to morphine / MGI

Literature references

  • Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells.;Plump A S, Smith J D, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft J G, Rubin E M, Breslow J L, ;1992;Cell;71;343-53; 1423598
  • Studies of mice lacking plasminogen activator gene function suggest that plasmin production prior to ovulation exceeds the amount needed for optimal ovulation efficiency.;Ny A, Nordström L, Carmeliet P, Ny T, ;1997;European journal of biochemistry;244;487-93; 9119016

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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