B6.129P2(Cg)-Parltm1.1Bdes/Ieg

Status

Available to order

EMMA IDEM:02075
International strain nameB6.129P2(Cg)-Parltm1.1Bdes/Ieg
Alternative nameParl
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolParltm1.1Bdes,
Gene/Transgene symbolParl

Information from provider

ProviderBart De Stropper
Provider affiliationFlanders interuniversitary institute for biotechnologies (VIB)
Genetic informationCre recombinase-mediated recombination in mice carrying the Parltm1Bdes allele (Parl conditional; EMMA strain ID EM:02076), resulted in the excision of exon 2, thus generating a Parl null allele (Parltm1.1Bdes).
Phenotypic informationSee: Cipolat S et al., "Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling." Cell 2006 Jul 14;126(1):163-75.
Breeding historyThe colony has been backcrossed 10 times.
References
  • Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.;Cipolat Sara, Rudka Tomasz, Hartmann Dieter, Costa Veronica, Serneels Lutgarde, Craessaerts Katleen, Metzger Kristine, Frezza Christian, Annaert Wim, D'Adamio Luciano, Derks Carmen, Dejaegere Tim, Pellegrini Luca, D'Hooge Rudi, Scorrano Luca, De Strooper Bart, ;2006;Cell;126;163-75; 16839884

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

MGI allele-associated human disease models

MGI phenotypes (allele matching)
  • kyphosis / MGI
  • abnormal male reproductive system morphology / MGI
  • small testis / MGI
  • postnatal growth retardation / MGI
  • respiratory distress / MGI
  • premature death / MGI
  • neurodegeneration / MGI
  • muscular atrophy / MGI
  • cryptorchism / MGI
  • increased neuron apoptosis / MGI
  • abnormal nervous system physiology / MGI
  • spleen atrophy / MGI
  • thymus atrophy / MGI
  • abnormal uterine environment / MGI
  • decreased skeletal muscle mass / MGI
  • small epididymis / MGI
  • abnormal B cell morphology / MGI
  • decreased lymphocyte cell number / MGI
  • decreased B cell number / MGI
  • decreased double-positive T cell number / MGI
  • cachexia / MGI
  • abnormal nerve conduction / MGI
  • abnormal cell physiology / MGI
  • abnormal mitochondrial physiology / MGI
  • increased T cell apoptosis / MGI
  • decreased skeletal muscle fiber diameter / MGI

Literature references

  • Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling.;Cipolat Sara, Rudka Tomasz, Hartmann Dieter, Costa Veronica, Serneels Lutgarde, Craessaerts Katleen, Metzger Kristine, Frezza Christian, Annaert Wim, D'Adamio Luciano, Derks Carmen, Dejaegere Tim, Pellegrini Luca, D'Hooge Rudi, Scorrano Luca, De Strooper Bart, ;2006;Cell;126;163-75; 16839884

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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