STOCK Rettm1Cos/Kctt

Status

Available to order

EMMA IDEM:02081
International strain nameSTOCK Rettm1Cos/Kctt
Alternative nameRet KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolRettm1Cos,
Gene/Transgene symbolRet

Information from provider

ProviderChristel Baudet
Provider affiliationUniversite Bordeaux 2
Genetic informationUbiquitous deletion of exons 12 and 13 after crossing the conditional Ret floxed allele with a cre-deleter strain, thereby generating a 'kinase dead receptor'. An FRT site is left in the genome after the excision of the FRT flanked neomycin cassette by flp recombinase.
Phenotypic informationHomozygous mice die at birth of kidney agenesis. Heterozygous mice are viable and fertile.
References
  • Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret.;Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V, ;1994;Nature;367;380-3; 8114940
  • Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development.;Schuchardt A, D'Agati V, Pachnis V, Costantini F, ;1996;Development (Cambridge, England);122;1919-29; 8674430
  • Retrograde signaling onto Ret during motor nerve terminal maturation.;Baudet Christel, Pozas Ester, Adameyko Igor, Andersson Elisabet, Ericson Johan, Ernfors Patrik, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;963-75; 18216204

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal enteric neuron morphology / MGI
  • intestinal hypoperistalsis / MGI
  • abnormal neurotransmitter secretion / MGI
  • single kidney / MGI
  • decreased renal glomerulus number / MGI
  • absent kidney / MGI
  • abnormal ureter morphology / MGI
  • absent superior cervical ganglion / MGI
  • abnormal stellate ganglion morphology / MGI
  • absent enteric neurons / MGI
  • abnormal lung development / MGI
  • abnormal kidney morphology / MGI
  • dilated renal tubules / MGI
  • small kidney / MGI
  • dilated renal glomerular capsule / MGI
  • abnormal ureter development / MGI
  • abnormal cardiac ganglion morphology / MGI
  • absent ureter / MGI
  • abnormal kidney collecting duct morphology / MGI
  • cardiovascular system phenotype / MGI
  • abnormal parasympathetic postganglionic fiber morphology / MGI
  • abnormal mesonephros morphology / MGI
  • abnormal branching involved in ureteric bud morphogenesis / MGI
  • abnormal ureteric bud elongation / MGI
  • abnormal ureteric bud invasion / MGI
  • abnormal metanephric mesenchyme morphology / MGI
  • abnormal kidney mesenchyme morphology / MGI
  • neonatal lethality, complete penetrance / MGI
  • increased metanephric mesenchyme apoptosis / MGI
  • absent nephrogenic zone / MGI
  • blind ureter / MGI
  • oligohydramnios / MGI
  • abnormal enteric neural crest cell migration / MGI
  • endocrine/exocrine gland phenotype / MGI
  • abnormal enteric nervous system morphology / MGI
  • abnormal enteric ganglia morphology / MGI
  • neoplasm / MGI
  • reproductive system phenotype / MGI
  • aganglionic megacolon / MGI
  • renal hypoplasia / MGI

Literature references

  • Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret.;Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V, ;1994;Nature;367;380-3; 8114940
  • Renal agenesis and hypodysplasia in ret-k- mutant mice result from defects in ureteric bud development.;Schuchardt A, D'Agati V, Pachnis V, Costantini F, ;1996;Development (Cambridge, England);122;1919-29; 8674430
  • Retrograde signaling onto Ret during motor nerve terminal maturation.;Baudet Christel, Pozas Ester, Adameyko Igor, Andersson Elisabet, Ericson Johan, Ernfors Patrik, ;2008;The Journal of neuroscience : the official journal of the Society for Neuroscience;28;963-75; 18216204

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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